{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:09:43Z","timestamp":1783944583394,"version":"3.55.0"},"reference-count":16,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A 37-year-old man presented with symptoms of polyuria and weight loss over the past year. Initial laboratory examination showed elevated blood glucose level (468\u2005mg\/dL [25.9\u2005mmol\/L]; normal reference range [RR], 75-109\u2005mg\/dL [4.1-6.0\u2005mmol\/L]), high glycated hemoglobin A1c (13.2% [120\u2005mmol\/mol]; RR, 4.6-6.2% [26-44\u2005mmol\/mol]), low urinary C-peptide excretion (17.4 \u03bcg\/day [5.76\u2005nmol\/day]; RR, 18.3-124.4 \u03bcg\/day [6.0-41.1\u2005nmol\/day]), and ketosis, leading to a diagnosis of insulin-dependent diabetes mellitus. Subsequent investigations identified medullary thyroid carcinoma and bilateral pheochromocytomas. Given the detected RET gene variant and the patient's family history of multiple endocrine neoplasia type 2A (MEN2A), the diagnosis of MEN2A was confirmed. Upon hospital admission, intensive insulin therapy was commenced, which resolved the symptoms and normalized blood glucose levels. Subsequently, laparoscopic bilateral adrenalectomy was performed, after which the patient's glucose tolerance normalized, eliminating the need for diabetes treatment and avoiding hypoglycemia. This case highlights the potential for catecholamine-induced suppression of insulin secretion via \u03b12 action on pancreatic \u03b2-cells to be remission and rapidly improved by adrenalectomy in individuals with MEN2A experiencing insulin-dependent diabetes mellitus.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae240","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T07:03:15Z","timestamp":1736406195000},"source":"Crossref","is-referenced-by-count":1,"title":["Remission of Insulin-Dependent Diabetes Mellitus in Multiple Endocrine Neoplasia Type 2A After Adrenalectomy"],"prefix":"10.1210","volume":"3","author":[{"given":"Megumi","family":"Sato","sequence":"first","affiliation":[{"name":"Division of Diabetology and Metabolism, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Shinjuku-ku , Tokyo 162-8666 ,","place":["Japan"]},{"name":"Division of Endocrinology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Shinjuku-ku , Tokyo 162-8666 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5947-8621","authenticated-orcid":false,"given":"Michio","family":"Otsuki","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Shinjuku-ku , Tokyo 162-8666 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Mori","sequence":"additional","affiliation":[{"name":"Division of Diabetology and Metabolism, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Shinjuku-ku , Tokyo 162-8666 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juro","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Tokyo Women's Medical University School of Medicine, Shinjuku-ku , Tokyo 162-8666 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics, Tokyo Women's Medical University , Shinjuku-ku, Tokyo 162-8666 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Nakagami","sequence":"additional","affiliation":[{"name":"Division of Diabetology and Metabolism, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Shinjuku-ku , Tokyo 162-8666 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"issue":"9","key":"2025011704220417000_luae240-B1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1097\/00004872-200309000-00020","article-title":"Diabetes as a marker of pheochromocytoma in hypertensive patients","volume":"21","author":"La Batide-Alanore","year":"2003","journal-title":"J Hypertens"},{"issue":"1","key":"2025011704220417000_luae240-B2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ando.2020.01.001","article-title":"Prevalence and progression of carbohydrate disorders in patients with pheochromocytoma\/paraganglioma: retrospective single-center study","volume":"81","author":"Elenkova","year":"2020","journal-title":"Ann. 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