{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:56:03Z","timestamp":1789584963819,"version":"build-2803163510"},"reference-count":12,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant genetic disorder characterized by neoplasia of the parathyroid, pancreatic islets, and anterior pituitary. In this report, we present a family case in which the proband was diagnosed with prolactinoma 25 years ago. During the current hospitalization, the patient was diagnosed with insulinoma, primary hyperparathyroidism, and adrenocortical carcinoma. The final diagnosis was MEN1, confirmed by identifying a heterozygous mutation in the MEN1 gene through genetic testing. The proband's son also tested positive for the same MEN1 gene mutation, although he exhibited no clinical symptoms. MEN1 associated with adrenocortical carcinoma is exceptionally rare, carries a high malignancy risk, and has a poor prognosis. Genetic testing for the MEN1 gene is crucial for accurate diagnosis, while family screening is beneficial for early detection, timely treatment, and improving patient outcomes.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae248","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T20:28:27Z","timestamp":1734467307000},"source":"Crossref","is-referenced-by-count":1,"title":["Multiple Endocrine Neoplasia Type 1 With Adrenal Cortical Adrenocortical Carcinoma: A 25-Year Follow-Up and Family Report"],"prefix":"10.1210","volume":"3","author":[{"given":"Mei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Third People's Hospital of Chengdu , Chengdu 610031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4324-6812","authenticated-orcid":false,"given":"Sha","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Third People's Hospital of Chengdu , Chengdu 610031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Wei","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Third People's Hospital of Chengdu , Chengdu 610031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"issue":"2","key":"2025021712070770500_luae248-B1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1210\/er.2013-1029","article-title":"Adrenocortical carcinoma","volume":"35","author":"Else","year":"2014","journal-title":"Endocr Rev"},{"issue":"1","key":"2025021712070770500_luae248-B2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ando.2023.09.003","article-title":"French guidelines from the GTE, AFCE and ENDOCAN-RENATEN (Groupe d'\u00e9tude des Tumeurs Endocrines\/Association Francophone de Chirurgie Endocrinienne\/Reseau national de prise en charge des tumeurs endocrines) for the screening, diagnosis and management of multiple endocrine neoplasia type 1","volume":"85","author":"Goudet","year":"2024","journal-title":"Ann Endocrinol (Paris)"},{"issue":"2","key":"2025021712070770500_luae248-B3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12020-017-1234-4","article-title":"Multiple endocrine neoplasia syndrome type 1: institution, management, and data analysis of a nationwide multicenter patient database","volume":"58","author":"Giusti","year":"2017","journal-title":"Endocrine"},{"issue":"5","key":"2025021712070770500_luae248-B4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.5603\/EP.a2019.0026","article-title":"Pituitary tumours in MEN1 syndrome\u2014the new insight into the diagnosis and treatment","volume":"70","author":"Rogozi\u0144ski","year":"2019","journal-title":"Endokrynol Pol"},{"issue":"4","key":"2025021712070770500_luae248-B5","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/PAS.0b013e31815ade45","article-title":"Pituitary tumors and hyperplasia in multiple endocrine neoplasia type 1 syndrome (MEN1): a case-control study in a series of 77 patients versus 2509 non-MEN1 patients","volume":"32","author":"Trouillas","year":"2008","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"2025021712070770500_luae248-B6","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1507\/endocrj.EJ12-0173","article-title":"Clinical features of insulinoma in patients with multiple endocrine neoplasia type 1: analysis of the database of the MEN Consortium of Japan","volume":"59","author":"Sakurai","year":"2012","journal-title":"Endocr J"},{"issue":"4","key":"2025021712070770500_luae248-B7","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-18-0608","article-title":"European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors","volume":"179","author":"Fassnacht","year":"2018","journal-title":"Eur J Endocrinol"},{"issue":"1-2","key":"2025021712070770500_luae248-B8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mce.2013.10.028","article-title":"Genetics and epigenetics of adrenocortical tumors","volume":"386","author":"Lerario","year":"2014","journal-title":"Mol Cell Endocrinol"},{"key":"2025021712070770500_luae248-B9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1477-7819-9-6","article-title":"Bilateral adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1 (MEN1) and a novel mutation in the MEN1 gene","volume":"9","author":"Griniatsos","year":"2011","journal-title":"World J Surg Oncol"},{"issue":"2","key":"2025021712070770500_luae248-B10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1530\/EJE-11-0679","article-title":"Adrenal involvement in MEN1. Analysis of 715 cases from the Groupe d'etude des Tumeurs Endocrines database","volume":"166","author":"Gatta-Cherifi","year":"2012","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"2025021712070770500_luae248-B11","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1530\/EC-18-0526","article-title":"Adrenocortical carcinoma in patients with MEN1: a kindred report and review of the literature","volume":"8","author":"Wang","year":"2019","journal-title":"Endocr Connect"},{"issue":"10","key":"2025021712070770500_luae248-B12","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1210\/jc.2009-0564","article-title":"Asymptomatic children with multiple endocrine neoplasia type 1 mutations may harbor nonfunctioning pancreatic neuroendocrine tumors","volume":"94","author":"Newey","year":"2009","journal-title":"J Clin Endocrinol Metab"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/3\/luae248\/61817580\/luae248.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/3\/luae248\/61817580\/luae248.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T12:07:24Z","timestamp":1739794044000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luae248\/8006256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,2,10]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luae248","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3]]},"published":{"date-parts":[[2025,2,10]]},"article-number":"luae248"}}