{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:32Z","timestamp":1753883612726,"version":"3.41.2"},"reference-count":12,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32ES010957"],"award-info":[{"award-number":["T32ES010957"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A male neonate exhibited hallmark features of Beckwith-Wiedemann syndrome (BWS) including large for gestational age, macroglossia, multiple ear pits, and umbilical hernia. He had neonatal hypoglycemia, requiring a glucose infusion rate of 9.7\u2005mg\/kg\/min. Over time, he demonstrated persistent hypoglycemia with point-of-care glucose &amp;lt;60\u2005mg\/dL (&amp;lt;3.3\u2005mmol\/L) (70-140\u2005mg\/dL, 3.9-7.8\u2005mmol\/L) prompting a critical sample. A diagnostic fast of 13\u2005hours revealed no hypoglycemia &amp;lt;50\u2005mg\/dL. However, he was found to have postprandial hypoglycemia after 2\u2005hours to 58\u2005mg\/dL (3.2\u2005mmol\/L) (70-140\u2005mg\/dL, 3.9-7.8\u2005mmol\/L) with low \u03b2-hydroxybutyrate of &amp;lt;1.8\u2005mg\/dL (&amp;lt;0.17\u2005mmol\/L) (&amp;gt;3.6\u2005mg\/dL, &amp;gt;1.8\u2005mmol\/L) and increased insulin 3.9\u2005\u03bcIU\/mL (27\u2005pmol\/L) (2-13\u2005\u03bcIU\/mL; 14-90\u2005pmol\/L). Low-dose diazoxide (6\u2005mg\/kg\/day) and chlorothiazide (10\u2005mg\/kg\/day) were initiated. After 48\u2005hours on diazoxide, all episodes of postprandial hypoglycemia resolved. A safety fast on diazoxide sustained blood glucose &amp;gt;70\u2005mg\/dL with a rise in serum \u03b2-hydroxybutyrate at 13 and 19\u2005hours. Our case highlights the heterogeneity of hypoglycemia in BWS, either fasting or postprandial. This emphasizes the importance of appropriate screening for both forms of hypoglycemia in patients with BWS and that diazoxide is an effective treatment.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae249","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T20:33:46Z","timestamp":1734986026000},"source":"Crossref","is-referenced-by-count":0,"title":["Postprandial Hypoglycemia in a Patient With Clinical Beckwith-Wiedemann Syndrome"],"prefix":"10.1210","volume":"3","author":[{"given":"Bella","family":"London","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati, OH 45229 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa Chiu","family":"Corker","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati, OH 45229 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lily","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati, OH 45229 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavapriya","family":"Mani","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati, OH 45229 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati, OH 45229 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