{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:47:27Z","timestamp":1787021247471,"version":"build-2736575974"},"reference-count":10,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rathke cleft cyst (RCC) is a benign, nonneoplastic cystic lesion arising from embryonic remnants of the Rathke pouch and is increasingly detected with the widespread use of brain magnetic resonance imaging (MRI). Most RCCs remain asymptomatic; however, some present with symptoms such as headaches, visual disturbances, or pituitary dysfunction, often attributed to inflammatory processes within the cyst wall. We report the case of a 68-year-old woman with a year-long history of intermittent headaches, polydipsia, and polyuria. Initial MRI revealed a cystic lesion in the sellar region, and endocrinological assessment confirmed arginine vasopressin deficiency. A serial MRI follow-up revealed recurrent, short-term fluctuations in cyst size, suggesting intermittent inflammatory activity within the RCC. Despite the option for surgical intervention, conservative management alone resulted in the resolution of her headaches and substantial cyst shrinkage. This case underscores the potential for conservative management in symptomatic RCCs with inflammatory features, where hormone replacement and careful imaging follow-up may suffice. It also highlights the need for individualized care and long-term monitoring, especially in cases with dynamic inflammatory behavior.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf008","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T10:06:57Z","timestamp":1739182017000},"source":"Crossref","is-referenced-by-count":2,"title":["Conservative Management of Symptomatic Rathke Cleft Cyst With Recurrent Inflammatory Remission"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7031-2446","authenticated-orcid":false,"given":"Masashi","family":"Hasebe","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine , Kyoto 606-8507 ,","place":["Japan"]},{"name":"Department of Diabetes and Endocrinology, Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-Kofukai , Osaka 530-8480 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3066-0442","authenticated-orcid":false,"given":"Ryo","family":"Tsukaguchi","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-Kofukai , Osaka 530-8480 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4576-4739","authenticated-orcid":false,"given":"Kimitaka","family":"Shibue","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-Kofukai , Osaka 530-8480 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1903-9752","authenticated-orcid":false,"given":"Akihiro","family":"Hamasaki","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-Kofukai , Osaka 530-8480 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"issue":"6","key":"2025021712065509300_luaf008-B1","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1210\/jc.2011-0168","article-title":"Pituitary magnetic resonance imaging for sellar and parasellar masses: ten-year experience in 2598 patients","volume":"96","author":"Famini","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2025021712065509300_luaf008-B2","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s11102-021-01194-9","article-title":"A study on clinical outcomes of Rathke's cleft cyst in patients managed conservatively","volume":"25","author":"Chong","year":"2022","journal-title":"Pituitary"},{"issue":"2","key":"2025021712065509300_luaf008-B3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1365-2265.2006.02446.x","article-title":"Magnetic resonance imaging, clinical manifestations, and management of Rathke's cleft cyst","volume":"64","author":"Nishioka","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"2025021712065509300_luaf008-B4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1507\/endocrj.K07E-070","article-title":"Rathke's cleft cyst with short-term size changes in response to glucocorticoid replacement","volume":"55","author":"Maruyama","year":"2008","journal-title":"Endocr J"},{"issue":"11","key":"2025021712065509300_luaf008-B5","first-page":"3972","article-title":"Cystic lesions of the pituitary: clinicopathological features distinguishing craniopharyngioma, Rathke's cleft cyst, and arachnoid cyst","volume":"84","author":"Shin","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2025021712065509300_luaf008-B6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.clineuro.2018.02.031","article-title":"Outcome of diabetes insipidus in patients with Rathke's cleft cysts","volume":"167","author":"Oishi","year":"2018","journal-title":"Clin Neurol Neurosurg"},{"issue":"2","key":"2025021712065509300_luaf008-B7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3171\/jns.2002.96.2.0209","article-title":"Changes in the epithelium of rathke cleft cyst associated with inflammation","volume":"96","author":"Hama","year":"2002","journal-title":"J Neurosurg"},{"issue":"10","key":"2025021712065509300_luaf008-B8","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1111\/j.1526-4610.2006.00539.x","article-title":"Headaches associated with Rathke's cleft cyst","volume":"46","author":"Nishioka","year":"2006","journal-title":"Headache"},{"issue":"2","key":"2025021712065509300_luaf008-B9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/cen.13744","article-title":"Natural history of Rathke's cleft cysts: a retrospective analysis of a two centres experience","volume":"89","author":"Sala","year":"2018","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"2025021712065509300_luaf008-B10","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1056\/NEJMoa1803760","article-title":"A copeptin-based approach in the diagnosis of diabetes insipidus","volume":"379","author":"Fenske","year":"2018","journal-title":"N Engl J Med"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/3\/luaf008\/61817621\/luaf008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/3\/luaf008\/61817621\/luaf008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T07:07:03Z","timestamp":1739776023000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luaf008\/8006260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,2,10]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luaf008","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3]]},"published":{"date-parts":[[2025,2,10]]},"article-number":"luaf008"}}