{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T01:17:05Z","timestamp":1772587025964,"version":"3.50.1"},"reference-count":18,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hyperthyroidism in twin pregnancies involving a hydatidiform mole and a coexisting live fetus is a rare condition requiring careful management. We present a 34-year-old pregnant woman at 12 weeks' gestation with severe nausea, vomiting, and mild vaginal bleeding. A transvaginal ultrasound revealed a dichorionic diamniotic twin pregnancy with 1 normal fetus and 1 hydatidiform mole, leading to hyperthyroidism from elevated \u03b2 human chorionic gonadotropin levels. Conservative management without antithyroid medications, combined with regular monitoring, allowed the pregnancy to continue to term, resulting in the delivery of a healthy baby at 39 weeks. Postpartum management required treatment of retained products of conception. This case highlights the complexities in the management of complications for both mother and fetus.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf013","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T10:39:55Z","timestamp":1737715195000},"source":"Crossref","is-referenced-by-count":1,"title":["Hyperthyroidism in a Twin Pregnancy With a Hydatidiform Mole and a Coexisting Live Fetus: Management Dilemmas"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9665-8361","authenticated-orcid":false,"given":"Samantha","family":"Jacobson","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada J1N 3C6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan-Rapha\u00ebl","family":"Stetco","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada J1N 3C6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, McGill University Health Center, Montr\u00e9al, QC, Canada H4A 3J1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2630-8298","authenticated-orcid":false,"given":"Natasha","family":"Garfield","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, McGill University Health Centre, Montr\u00e9al, QC, Canada H4A 3J1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"2025020513053584800_luaf013-B1","first-page":"651","article-title":"Molar pregnancy with co-existing viable Fetus delivered preterm at 24 weeks gestation: a case report","volume":"16","author":"Hassan","year":"2023","journal-title":"Int Med Case Rep J"},{"issue":"9324","key":"2025020513053584800_luaf013-B2","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1016\/S0140-6736(02)09085-2","article-title":"Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin","volume":"359","author":"Sebire","year":"2002","journal-title":"Lancet"},{"key":"2025020513053584800_luaf013-B3","first-page":"100190","article-title":"Hyperthyroidism in the pregnant woman: maternal and fetal aspects","volume":"16","author":"Moleti","year":"2019","journal-title":"J Clin Transl Endocrinol"},{"issue":"1","key":"2025020513053584800_luaf013-B4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13044-021-00092-3","article-title":"Hyperthyroidism in gestational trophoblastic disease\u2014a literature review","volume":"14","author":"Pereira","year":"2021","journal-title":"Thyroid Res"},{"issue":"11","key":"2025020513053584800_luaf013-B5","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1038\/bjc.2011.139","article-title":"Hyperthyroidism and human chorionic gonadotrophin production in gestational trophoblastic disease","volume":"104","author":"Walkington","year":"2011","journal-title":"Br J Cancer"},{"issue":"2","key":"2025020513053584800_luaf013-B6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.beem.2004.03.010","article-title":"Physiological and pathological aspects of the effect of human chorionic gonadotropin on the thyroid","volume":"18","author":"Hershman","year":"2004","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2025020513053584800_luaf013-B7","volume-title":"StatPearls","author":"Sorah","year":"2024"},{"issue":"4","key":"2025020513053584800_luaf013-B8","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1210\/jc.2015-4274","article-title":"Antithyroid drug Side effects in the population and in pregnancy","volume":"101","author":"Andersen","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2025020513053584800_luaf013-B9","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.fertnstert.2012.06.048","article-title":"Evaluation and treatment of recurrent pregnancy loss: a committee opinion","volume":"98","year":"2012","journal-title":"Fertil Steril"},{"key":"2025020513053584800_luaf013-B10","first-page":"86","volume-title":"Endocrine Development","author":"Obregon","year":"2007"},{"issue":"2","key":"2025020513053584800_luaf013-B11","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.beem.2004.03.009","article-title":"Fetal and neonatal thyroid function in relation to maternal Graves' disease","volume":"18","author":"Polak","year":"2004","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"1","key":"2025020513053584800_luaf013-B12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40842-018-0054-7","article-title":"Graves' hyperthyroidism in pregnancy: a clinical review","volume":"4","author":"Nguyen","year":"2018","journal-title":"Clin Diabetes Endocrinol"},{"issue":"4","key":"2025020513053584800_luaf013-B13","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1097\/01.AOG.0000462945.27539.93","article-title":"Practice bulletin No. 148: thyroid disease in pregnancy","volume":"125","year":"2015","journal-title":"Obstet Gynecol"},{"issue":"11","key":"2025020513053584800_luaf013-B14","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/OGX.0000000000000367","article-title":"Diagnosis and management of hyperthyroidism in pregnancy: a review","volume":"71","author":"King","year":"2016","journal-title":"Obstet Gynecol Surv"},{"issue":"9742","key":"2025020513053584800_luaf013-B15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(10)60280-2","article-title":"Gestational trophoblastic disease","volume":"376","author":"Seckl","year":"2010","journal-title":"Lancet"},{"issue":"11","key":"2025020513053584800_luaf013-B16","first-page":"e19656","article-title":"Molar pregnancy complicated by impending thyroid storm","volume":"13","author":"Sharma","year":"2021","journal-title":"Cureus"},{"key":"2025020513053584800_luaf013-B17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ygyno.2023.01.016","article-title":"Presentation, medical complications and development of gestational trophoblastic neoplasia of hydatidiform mole after intracytoplasmic sperm injection as compared to hydatidiform mole after spontaneous conception\u2014a retrospective cohort study and literature review","volume":"170","author":"Braga","year":"2023","journal-title":"Gynecol Oncol"},{"issue":"11","key":"2025020513053584800_luaf013-B18","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.6004\/jnccn.2019.7364","article-title":"State-of-the-Art workup and initial management of newly diagnosed molar pregnancy and postmolar gestational trophoblastic neoplasia","volume":"17","author":"Elias","year":"2019","journal-title":"J Natl Compr Canc Netw"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/2\/luaf013\/61617318\/luaf013.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/2\/luaf013\/61617318\/luaf013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T13:08:48Z","timestamp":1738760928000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luaf013\/7978321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,20]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1,20]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luaf013","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2025,1,20]]},"article-number":"luaf013"}}