{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T02:50:05Z","timestamp":1785034205566,"version":"3.55.0"},"reference-count":11,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A 26-year-old male with medical history of polycystic kidney disease, IgA nephropathy, end-stage renal disease, and brown tumor (requiring prior surgical intervention on brown tumor) was hospitalized because of right lower extremity weakness. Examination revealed right hip flexor weakness and right foot clonus. Laboratory results showed serum calcium of 10.4\u2005mg\/dL (2.59\u2005mmol\/L) (reference range: 8.5-10.5\u2005mg\/dL; 2.12-2.62\u2005mmol\/L). Magnetic resonance imaging displayed a 2.5\u2005\u00d7 3.7\u2005cm soft tissue mass with circumferential encroachment of the epidural space leading to severe spinal canal stenosis of T4-T5 at the site of prior brown tumor resection. The patient underwent subtotal parathyroidectomy with left cervical thymectomy, leading to an intraoperative PTH drop from &amp;gt;3500\u2005pg\/mL (&amp;gt;371\u2005pmol\/L) (reference range: 12-88\u2005pg\/mL; 1.27-9.33\u2005pmol\/L) to 247\u2005pg\/mL (26.182\u2005pmol\/L). In the context of treating vertebral brown tumors, the consensus suggests that parathyroidectomy plays a crucial role in achieving both clinical and radiographical amelioration of the tumor. However, in cases like ours where paresis is present, surgical decompression of the tumor becomes imperative. The development of brown tumors is an uncommon and severe, long-term complication for hyperparathyroidism. The location of a brown tumor in the thoracic spine causing symptomatic cord compression is rare.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf022","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T23:56:56Z","timestamp":1742515016000},"source":"Crossref","is-referenced-by-count":1,"title":["From Secondary Hyperparathyroidism to Neurologic Crisis: A Tale of Brown Tumor and Spinal Cord Compression"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5421-694X","authenticated-orcid":false,"given":"Aryn","family":"Kormanis","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Atrium Health Wake Forest Baptist Medical Center , Winston-Salem, NC 27157, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Atrium Health Wake Forest Baptist Medical Center , Winston-Salem, NC 27157, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miya","family":"McKnight","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Atrium Health Wake Forest Baptist Medical Center , Winston-Salem, NC 27157, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hima","family":"Darapu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Atrium Health Wake Forest Baptist Medical Center , Winston-Salem, NC 27157, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"issue":"4","key":"2025032012383962200_luaf022-B1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/1744-9987.12772","article-title":"Secondary hyperparathyroidism: pathogenesis and latest treatment","volume":"23","author":"Mizobuchi","year":"2019","journal-title":"Ther Apher Dial"},{"issue":"13","key":"2025032012383962200_luaf022-B2","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.3390\/jcm13133847","article-title":"Brown tumors: the hidden face of primary and renal hyperparathyroidism amid real-life settings","volume":"13","author":"Carsote","year":"2024","journal-title":"J Clin Med"},{"key":"2025032012383962200_luaf022-B3","volume-title":"StatPearls","author":"Naji Rad","year":"2023"},{"issue":"6","key":"2025032012383962200_luaf022-B4","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1080\/02688697.2016.1199789","article-title":"A thoracic vertebral brown tumor presenting with paraparesis in a patient with end-stage renal disease","volume":"31","author":"Solmaz","year":"2017","journal-title":"Br J Neurosurg"},{"issue":"6","key":"2025032012383962200_luaf022-B5","doi-asserted-by":"crossref","first-page":"e32768","DOI":"10.1097\/MD.0000000000032768","article-title":"Brown tumor of the cervical spine with primary hyperparathyroidism: a case report and literature review","volume":"102","author":"Liu","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"2025032012383962200_luaf022-B6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ijscr.2021.01.002","article-title":"Multiple brown tumors with primary hyperparathyroidism mimicking bone metastases","volume":"79","author":"Ngo","year":"2021","journal-title":"Int J Surg Case Rep"},{"issue":"1","key":"2025032012383962200_luaf022-B7","doi-asserted-by":"crossref","first-page":"208.e1","DOI":"10.1016\/j.wneu.2010.02.022","article-title":"Vertebral brown tumors causing neurologic compromise","volume":"79","author":"Fargen","year":"2013","journal-title":"World Neurosurg"},{"key":"2025032012383962200_luaf022-B8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s13730-019-00398-0","article-title":"Brown tumor of the thoracic spine presenting with paraplegia in a patient with peritoneal dialysis","volume":"8","author":"Eroglu","year":"2019","journal-title":"CEN Case Rep"},{"key":"2025032012383962200_luaf022-B9","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ijscr.2018.09.023","article-title":"Brown tumor of the cervical spine in a patient with secondary hyperparathyroidism: a case report","volume":"51","author":"S\u00e1nchez-Calder\u00f3n","year":"2018","journal-title":"Int J Surg Case Rep"},{"issue":"6","key":"2025032012383962200_luaf022-B10","doi-asserted-by":"crossref","first-page":"952","DOI":"10.2215\/CJN.10390917","article-title":"Parathyroidectomy in the management of secondary hyperparathyroidism","volume":"13","author":"Lau","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"2025032012383962200_luaf022-B11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/hdi.13067","article-title":"Hungry bone syndrome after parathyroid surgery","volume":"27","author":"Tai","year":"2023","journal-title":"Hemodial Int"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/4\/luaf022\/62490646\/luaf022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/4\/luaf022\/62490646\/luaf022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T23:57:15Z","timestamp":1742515035000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luaf022\/8087988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,17]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,3,17]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luaf022","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,3,17]]},"article-number":"luaf022"}}