{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T19:21:22Z","timestamp":1769800882889,"version":"3.49.0"},"reference-count":13,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hyperparathyroidism-jaw tumor syndrome (HPT-JT) is a hereditary neoplastic disorder caused by a pathogenic variant in the CDC73 tumor suppressor gene. It is characterized by increased values of PTH, ossifying fibromas of the jaws, and in some cases neoplasms of the kidneys\/or the uterus. We present a case of a 65-year-old male who had several jaw tumors with secondary infection requiring treatment. Previous medical history included parathyroid adenomas with a long history of increased PTH and kidney tumor. This prompted genetic testing, which confirmed a heterozygous CDC73 pathogenic variant, establishing the diagnosis of HPT-JT. The jaw tumor was excised. The patient was referred to genetic counselling but declined.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf049","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:17:24Z","timestamp":1742516244000},"source":"Crossref","is-referenced-by-count":1,"title":["Hyperparathyroidism-Jaw Tumor Syndrome: A Case Diagnosed After the Removal of Multiple Ossifying Fibromas of the Jaws"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4145-0481","authenticated-orcid":false,"given":"P\u00e5l Steinmo","family":"Johnsen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Division of Oral and Maxillofacial Surgery, Nordland Hospital Trust , Bod\u00f8 8092 ,","place":["Norway"]},{"name":"Department of Clinical Dentistry, UiT the Arctic University of Norway , Troms\u00f8 9019 ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Division of Oral and Maxillofacial Surgery, Nordland Hospital Trust , Bod\u00f8 8092 ,","place":["Norway"]},{"name":"Department of Clinical Dentistry, UiT the Arctic University of Norway , Troms\u00f8 9019 ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja Nilsen","family":"Nyland","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Division of Oral and Maxillofacial Surgery, Nordland Hospital Trust , Bod\u00f8 8092 ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Al-Shibli","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nordland Hospital Trust , Bod\u00f8 8092 ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Frid","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, UiT the Arctic University of Norway , Troms\u00f8 9019 ,","place":["Norway"]},{"name":"Department of Otorhinolaryngology, Division of Oral and Maxillofacial Surgery, University Hospital North Norway , Troms\u00f8 9038 ,","place":["Norway"]},{"name":"Public Dental Service Competence Centre of North Norway , Troms\u00f8 9019 ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"issue":"3","key":"2025032013504369900_luaf049-B1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/humu.21188","article-title":"Cell division cycle protein 73 homolog (CDC73) mutations in the hyperparathyroidism-jaw tumor syndrome (HPT-JT) and parathyroid tumors","volume":"31","author":"Newey","year":"2010","journal-title":"Hum Mutat"},{"issue":"12","key":"2025032013504369900_luaf049-B2","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1210\/clinem\/dgad368","article-title":"Phenotypic profiling and molecular mechanisms in hyperparathyroidism-jaw tumor syndrome","volume":"108","author":"Tora","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2025032013504369900_luaf049-B3","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ng1048","article-title":"HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome","volume":"32","author":"Carpten","year":"2002","journal-title":"Nat Genet"},{"issue":"1","key":"2025032013504369900_luaf049-B4","first-page":"64","article-title":"Jaw tumor in primary hyperparathyroidism is not always a brown tumor","volume":"13","author":"Ennazk","year":"2016","journal-title":"Clin Cases Miner Bone 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