{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:18:14Z","timestamp":1787847494245,"version":"build-2784847793"},"reference-count":24,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lipodystrophies are rare disorders characterized by loss of body fat resulting in leptin deficiency. Patients are predisposed to metabolic complications such as severe insulin resistance, hypertriglyceridemia, and hepatic steatosis. Werner syndrome (WS) is among the progeroid syndromes in the classification of lipodystrophy. In this case report, we describe two siblings. In the first case, lipodystrophy was suspected when the patient presented with acute pancreatitis and hypertriglyceridemia, and a diagnosis of WS was confirmed. Subsequently, genetic screening of the patient's sister, who had early-onset diabetes, also revealed WS.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf061","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T07:41:26Z","timestamp":1744270886000},"source":"Crossref","is-referenced-by-count":1,"title":["A Rare Cause of Acute Pancreatitis: Two Siblings With Werner Syndrome"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3254-7815","authenticated-orcid":false,"given":"Kenan","family":"Sakar","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Mugla Sitki Kocman University , Mugla 48000 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baris","family":"Akinci","sequence":"additional","affiliation":[{"name":"Izmir International Biomedicine and Genome Institute, Dokuz Eylul University , Izmir 35340 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilgin Yildirim","family":"Simsir","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Ege University , Izmir 35100 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-3872","authenticated-orcid":false,"given":"Tahir","family":"Atik","sequence":"additional","affiliation":[{"name":"Department of Child Genetic Diseases, Ege University , Izmir 35100 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulhan","family":"Akbaba","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Mugla Sitki Kocman University , Mugla 48000 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nese","family":"Cinar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Mugla 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