{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:25Z","timestamp":1753883605115,"version":"3.41.2"},"reference-count":16,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ovarian carcinoid tumors (OCTs) are rare and may cause carcinoid syndrome (CS) even in the absence of liver metastases. Carcinoid heart disease (CHD), which develops in up to 50% of patients with CS, substantially affects morbidity and mortality. While prognosis is generally favorable, maintaining clinical suspicion and early diagnosis is crucial to prevent the development of advanced heart failure or metastases. We present a case of a woman exhibiting asthenia, diarrhea, and de novo severe hypertension. Echocardiography revealed typical features of CHD. Elevated urinary levels of 5-hydroxyindoleacetic acid (5-HIAA) corroborated the diagnosis of CS. 68Ga-DOTANOC positron emission tomography computed tomography identified a suspicious left pelvic mass, which was subsequently confirmed by magnetic resonance imaging. Surgical resection of the tumor was performed, followed by tricuspid valve replacement surgery, confirming the diagnosis of OCT associated with CS and CHD. Postoperative follow-up revealed considerable clinical improvement, and the patient has remained free of recurrence. This case underscores the complex cardiovascular involvement in CS, with secondary hypertension as the initial symptomatic manifestation, which improved following resection of OCT. Additionally, it highlights the role of CS in the pathogenesis of severe tricuspid valve dysfunction, which ultimately required cardiac surgery.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf073","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T04:46:16Z","timestamp":1744865176000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypertension and Carcinoid Heart Disease as Initial Manifestations of Ovarian Carcinoid Tumor"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2158-4714","authenticated-orcid":false,"given":"Andreia","family":"Martins Fernandes","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Instituto Portugu\u00eas de Oncologia de Coimbra Francisco Gentil , E.P.E., Coimbra 3000-075 ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Pathology, Instituto Portugu\u00eas de Oncologia de Coimbra Francisco Gentil, E.P.E. , Coimbra 3000-075 ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina","family":"Neves","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Instituto Portugu\u00eas de Oncologia de Coimbra Francisco Gentil , E.P.E., Coimbra 3000-075 ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Prieto","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Center, Centro Hospitalar e Universit\u00e1rio de Coimbra , E.P.E., Coimbra 3000-075 ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Aldinhas","sequence":"additional","affiliation":[{"name":"Department of Ginecology, Instituto Portugu\u00eas de Oncologia de Coimbra Francisco Gentil , E.P.E., Coimbra 3000-075 ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"G. 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