{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:54:46Z","timestamp":1753883686756,"version":"3.41.2"},"reference-count":11,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Thymic hyperplasia (TH) is a rare but established complication of Graves disease (GD). It is a benign phenomenon that regresses with appropriate treatment of GD. We report the case of a Burmese refugee with newly diagnosed GD, who had an incidental thymic mass measuring 70\u2005mm \u00d7 21\u2005mm \u00d7 121\u2005mm. The size of the mass exceeded typical reports in the literature but was not accompanied by a substantial thyrotoxicosis. As the mass receded with antithyroid medication, a presumptive diagnosis of TH was ultimately made. Recognition of this association is vital to prevent unnecessary biopsy and surgical intervention.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf076","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T10:09:28Z","timestamp":1746698968000},"source":"Crossref","is-referenced-by-count":0,"title":["Massive Thymic Hyperplasia in Graves Disease"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3225-4123","authenticated-orcid":false,"given":"Christopher","family":"Chan","sequence":"first","affiliation":[{"name":"Logan Endocrine and Diabetes Service, Logan Hospital, Metro South Health , Meadowbrook, Brisbane, QLD 4131 ,","place":["Australia"]},{"name":"School of Medicine and Dentistry, Griffith University, Southport , Brisbane, QLD 4222 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Ryder","sequence":"additional","affiliation":[{"name":"Logan Endocrine and Diabetes Service, Logan Hospital, Metro South Health , Meadowbrook, Brisbane, QLD 4131 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianna","family":"Luong","sequence":"additional","affiliation":[{"name":"Logan Endocrine and Diabetes Service, Logan Hospital, Metro South Health , Meadowbrook, Brisbane, QLD 4131 ,","place":["Australia"]},{"name":"School of Medicine, University of Queensland , Herston, Brisbane, QLD 4006 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Puri","sequence":"additional","affiliation":[{"name":"Logan Endocrine and Diabetes Service, Logan Hospital, Metro South Health , Meadowbrook, Brisbane, QLD 4131 ,","place":["Australia"]},{"name":"Clinical Excellence Queensland , Herston, Brisbane, QLD 4006 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"issue":"8","key":"2025050806092005700_luaf076-B1","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1089\/thy.2017.0086","article-title":"Thymic hyperplasia associated with Graves' disease: pathophysiology and proposed management algorithm","volume":"27","author":"Haider","year":"2017","journal-title":"Thyroid"},{"key":"2025050806092005700_luaf076-B2","first-page":"287","article-title":"The significance of the thymus in Graves' disease: report of two cases of resection of the thymus gland","volume":"32","author":"Halsted","year":"1914","journal-title":"Trans Am Surg Assoc"},{"issue":"3","key":"2025050806092005700_luaf076-B3","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1210\/jcem-62-3-474","article-title":"Thyroid function modulates thymic endocrine activity","volume":"62","author":"Fabris","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2025050806092005700_luaf076-B4","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1172\/JCI119032","article-title":"Thymic hyperplasia in patients with Graves' disease. Identification of thyrotropin receptors in human thymus","volume":"98","author":"Murakami","year":"1996","journal-title":"J Clin Invest"},{"issue":"4","key":"2025050806092005700_luaf076-B5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1089\/105072504323030979","article-title":"A case of thymic enlargement in hyperthyroidism in a young woman","volume":"14","author":"Nakamura","year":"2004","journal-title":"Thyroid"},{"issue":"6","key":"2025050806092005700_luaf076-B6","doi-asserted-by":"crossref","first-page":"534","DOI":"10.4158\/EP09025.ORR","article-title":"Thymic hyperplasia and Graves disease: management of anterior mediastinal masses in patients with Graves disease","volume":"15","author":"Yacoub","year":"2009","journal-title":"Endocr Pract"},{"issue":"3","key":"2025050806092005700_luaf076-B7","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1148\/radiol.2433060797","article-title":"Thymic hyperplasia and thymus gland tumors: differentiation with chemical shift MR imaging","volume":"243","author":"Inaoka","year":"2007","journal-title":"Radiology"},{"issue":"5","key":"2025050806092005700_luaf076-B8","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/0003-4975(89)90131-8","article-title":"True thymic hyperplasia: a clinicopathological study","volume":"47","author":"Ricci","year":"1989","journal-title":"Ann Thorac Surg"},{"issue":"5-6","key":"2025050806092005700_luaf076-B9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3109\/08916930903563491","article-title":"Thymic remodeling associated with hyperplasia in myasthenia gravis","volume":"43","author":"Le Panse","year":"2010","journal-title":"Autoimmunity"},{"issue":"12","key":"2025050806092005700_luaf076-B10","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s40618-014-0157-7","article-title":"Thymic hyperplasia in patients with Graves' disease","volume":"37","author":"Dalla Costa","year":"2014","journal-title":"J Endocrinol Invest"},{"issue":"7","key":"2025050806092005700_luaf076-B11","first-page":"852","article-title":"Thymic involution after radioiodine therapy for Graves disease: relationships with serum thyroid hormones and TRAb","volume":"1","author":"Jinguji","year":"2017","journal-title":"J Endocr Soc"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/6\/luaf076\/63115695\/luaf076.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/6\/luaf076\/63115695\/luaf076.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T10:09:30Z","timestamp":1746698970000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luaf076\/8126880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,18]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,4,18]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luaf076","relation":{},"ISSN":["2755-1520"],"issn-type":[{"type":"electronic","value":"2755-1520"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,4,18]]},"article-number":"luaf076"}}