{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:22Z","timestamp":1753883602995,"version":"3.41.2"},"reference-count":8,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>While adrenal androgen production is primarily regulated by ACTH, some data suggest a less common association between hyperprolactinemia and elevated dehydroepiandrosterone sulfate (DHEA-S). We describe 2 patients with this underrecognized connection. Patient 1, a 60-year-old male, was incidentally found to have bilateral adrenal masses on computed tomography during evaluation of gastrointestinal complaints. Further workup revealed elevated levels of DHEA-S and prolactin, with pituitary macroadenoma identified as the cause, given normalization of both prolactin and DHEA-S on cabergoline therapy. Patient 2, a 38-year-old male, presented with visual field defects, and subsequent pituitary magnetic resonance imaging confirmed a macroadenoma. He also had markedly elevated levels of DHEA-S and prolactin. Both patients were treated with cabergoline, leading to rapid normalization of both prolactin and DHEA-S levels. These cases demonstrate an association between hyperprolactinemia and elevated DHEA-S, supported by the normalization of levels with medical treatment of prolactinoma. Although hyperprolactinemia in the context of a prolactinoma is an uncommon cause of elevated DHEA-S, it should be considered once other etiologies have been excluded.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf111","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T08:52:44Z","timestamp":1747299164000},"source":"Crossref","is-referenced-by-count":0,"title":["Elevated Dehydroepiandrosterone Sulfate Levels in 2 Patients With Prolactinomas: An Underrecognized Association"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4114-3572","authenticated-orcid":false,"given":"Joseph","family":"Arguinchona","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Mayo Clinic Arizona , Scottsdale, AZ 85259 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditi","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Mayo Clinic Arizona , Scottsdale, AZ 85259 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Yogi-Morren","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Cleveland Clinic , Cleveland, OH 44195 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7174-1332","authenticated-orcid":false,"given":"Mona","family":"Vahidi Rad","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Mayo Clinic Arizona , Scottsdale, AZ 85259 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krupa","family":"Doshi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Mayo Clinic Arizona , Scottsdale, AZ 85259 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