{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:10:22Z","timestamp":1771654222432,"version":"3.50.1"},"reference-count":13,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Postmenopausal virilization accompanied by insulin resistance is rare and may present as a diagnostic challenge. Ovarian hyperthecosis is characterized by ovarian stromal cell proliferation, leading to androgen excess and associated insulin resistance. Here, we present a case of a 58-year-old postmenopausal woman with new onset virilization and associated type 2 diabetes due to ovarian hyperthecosis, who was successfully treated with bilateral oophorectomy, resulting in normalization of hyperandrogenism and improvement in glycemic control along with metformin and lifestyle advice. This case underscores the importance of recognizing ovarian hyperthecosis as a differential diagnosis when assessing new onset virilization and metabolic disturbance in postmenopausal women.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf118","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T06:13:31Z","timestamp":1748499211000},"source":"Crossref","is-referenced-by-count":1,"title":["Ovarian Hyperthecosis Presenting With Postmenopausal Virilization and New-Onset Type 2 Diabetes"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9981-5384","authenticated-orcid":false,"given":"Jeremy A","family":"Knott","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Wollongong Hospital , Wollongong, NSW 2500 ,","place":["Australia"]},{"name":"St George and Sutherland Clinical School, University of New South Wales , Sydney, NSW 2217 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shoalhaven District Memorial Hospital ISLHD , Nowra, NSW 2541 ,","place":["Australia"]},{"name":"Graduate School of Medicine, University of Wollongong , Wollongong, NSW 2522 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"2025052902132682100_luaf118-B1","first-page":"2783464","article-title":"Postmenopausal hyperandrogenism due to ovarian hyperthecosis","volume":"2023","author":"Metzker","year":"2023","journal-title":"Case Rep Obstet Gynecol"},{"issue":"1","key":"2025052902132682100_luaf118-B2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/humupd\/dmp024","article-title":"Visually scoring hirsutism","volume":"16","author":"Yildiz","year":"2010","journal-title":"Hum 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women","volume":"81","author":"Moghetti","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2025052902132682100_luaf118-B9","doi-asserted-by":"crossref","first-page":"2050313X231178404","DOI":"10.1177\/2050313X231178404","article-title":"Surgical treatment of postmenopausal ovarian hyperandrogenism improves glucometabolic profile alongside clinical hirsutism","volume":"11","author":"De Taddeo","year":"2023","journal-title":"SAGE Open Med Case Rep"},{"issue":"Supplement_1","key":"2025052902132682100_luaf118-B10","doi-asserted-by":"crossref","first-page":"A289","DOI":"10.1210\/jendso\/bvac150.596","article-title":"LBSUN288 improved glycemic control following oophorectomy in A postmenopausal woman with ovarian hyperthecosis","volume":"6","author":"Learned","year":"2022","journal-title":"J Endocr Soc"},{"issue":"6","key":"2025052902132682100_luaf118-B11","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0002-9343(97)00254-4","article-title":"Efficacy of 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