{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:02:13Z","timestamp":1752192133872,"version":"3.41.2"},"reference-count":21,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We report a case of spontaneous resolution of Cushing disease (CD). A 20-year-old female individual, previously healthy, was referred for investigation of galactorrhea and a prolactin level of 31 ng\/mL (&amp;lt;20 ng\/mL) (SI: 31 \u00b5g\/L, &amp;lt;20 \u00b5g\/L). A magnetic resonance imaging (MRI) scan revealed an 11 mm pituitary lesion. Cabergoline was commenced to address symptomatic hyperprolactinemia. Over the following months, signs of hypercortisolism evolved. Initial tests revealed a positive 1-mg dexamethasone suppression test (DST), prompting further evaluation. Midnight salivary and 24-hour urinary free cortisol tests confirmed hypercortisolism, consistent with a pituitary source which was confirmed with a peripheral corticotropin-releasing hormone (CRH) stimulation test. While cabergoline successfully resolved the galactorrhea, an MRI scan 6 months later showed an increase in the pituitary lesion\u2019s size, leading to neurosurgical referral. However, a preoperative MRI surprisingly revealed complete resolution of the pituitary mass, which coincided with the normalization of hypercortisolism symptoms and laboratory results. This rare case of spontaneous remission, while possibly influenced by cabergoline or undetected pituitary apoplexy, contributes valuable insights into the unpredictable nature of CD and its treatment.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf131","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T06:49:22Z","timestamp":1752130162000},"source":"Crossref","is-referenced-by-count":0,"title":["A Case of Spontaneously Resolving Cushing Disease"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8753-6386","authenticated-orcid":false,"given":"Aongus","family":"O\u2019Brolchain","sequence":"first","affiliation":[{"name":"Logan Endocrine and Diabetes Service, Meadowbrook Medical Centre , Meadowbrook, QLD 4131 ,","place":["Australia"]},{"name":"Griffith University, 58 Parklands Drive, Southport, QLD 4215 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Ryder","sequence":"additional","affiliation":[{"name":"Logan Endocrine and Diabetes Service, Meadowbrook Medical Centre , Meadowbrook, QLD 4131 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Berkman","sequence":"additional","affiliation":[{"name":"Logan Endocrine and Diabetes Service, Meadowbrook Medical Centre , Meadowbrook, QLD 4131 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"issue":"4","key":"2025071002491731800_luaf131-B1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1210\/er.2013-1048","article-title":"The treatment of Cushing\u2019s disease","volume":"36","author":"Pivonello","year":"2015","journal-title":"Endocr Rev"},{"key":"2025071002491731800_luaf131-B2","author":"Chiang"},{"issue":"6","key":"2025071002491731800_luaf131-B3","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.ando.2021.10.002","article-title":"Spontaneous remission of Cushing\u2019s disease: a systematic review","volume":"82","author":"Popa Ilie","year":"2021","journal-title":"Ann Endocrinol (Paris)"},{"issue":"8","key":"2025071002491731800_luaf131-B4","doi-asserted-by":"crossref","first-page":"e13167","DOI":"10.1111\/jne.13167","article-title":"Cushing\u2019s syndrome update: 100 years after Minnie G","volume":"34","author":"Millar","year":"2022","journal-title":"J Neuroendocrinol"},{"issue":"4","key":"2025071002491731800_luaf131-B5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s11102-010-0248-1","article-title":"The elusive Minnie G. 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