{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:36:41Z","timestamp":1783741001643,"version":"3.55.0"},"reference-count":15,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ectopic ACTH secretion is a rare, severe condition covering a wide spectrum of tumors of different location and aggressiveness. The usual poor prognosis of patients with ectopic ACTH secretion requires prompt management. We report a case of a patient with high surgical risk and intolerance to cortisol-lowering drug, in which hypercortisolism was successfully treated with radiofrequency ablation of a lung carcinoid tumor. A 78-year-old woman was referred for a rapidly progressive ACTH-dependent Cushing syndrome (CS). Biological tests suggested the presence of CS due to ectopic ACTH production. Imaging studies detected an 11-mm left upper pulmonary lobe nodule. A computed tomography-guided biopsy of the lesion confirmed a well-differentiated ACTH-positive carcinoid tumor with a Ki67 index &amp;lt;10%. The patient started therapy with ketoconazole but developed severe gastrointestinal side effects. Because of a very high surgical risk, lung resection was prohibited. Radiofrequency ablation of the lung carcinoid tumor was performed without major complication. The procedure allowed a progressive control of hypercortisolism with rapid improvement of CS that persists after 1 year. We show that radiofrequency ablation may be an efficient alternative treatment for the management of high surgical risk patients with ectopic ACTH syndrome secondary to a well-differentiated lung carcinoid tumor.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf143","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T08:03:23Z","timestamp":1752134603000},"source":"Crossref","is-referenced-by-count":1,"title":["Radiofrequency Ablation: Alternative Treatment of Ectopic Adrenocorticotropic Syndrome Secondary to Lung Carcinoid Tumor"],"prefix":"10.1210","volume":"3","author":[{"given":"Claire","family":"Barani","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Cliniques Universitaires Saint-Luc UCL , Bruxelles ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Fran\u00e7ois","family":"Goyers","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinique CHC MontL\u00e9gia , Li\u00e9ge ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Hoton","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cliniques Universitaires Saint-Luc UCL , Bruxelles ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0918-637X","authenticated-orcid":false,"given":"Dominique","family":"Maiter","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Cliniques Universitaires Saint-Luc UCL , Bruxelles ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-0504","authenticated-orcid":false,"given":"Raluca Maria","family":"Furnica","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Cliniques Universitaires Saint-Luc UCL , Bruxelles 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