{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:32:17Z","timestamp":1791909137952,"version":"4.3.4"},"reference-count":18,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Malignant struma ovarii (MSO) is a rare malignant teratoma of the ovary composed predominantly of malignant thyroid tissue, often resembling papillary or follicular thyroid carcinoma. We present a case of Stage 1A MSO, in remission 5 years post-treatment, alongside a review of the literature. The patient, who presented with right-sided abdominal pain, had imaging that revealed a right adnexal mass. Pathology confirmed papillary thyroid carcinoma (PTC) confined to the right ovary. Surveillance included computed tomography (CT) scans and transvaginal ultrasounds, all negative for recurrence at 5 years. A literature review underscores the importance of pathology in diagnosing MSO, with treatment dependent on tumor aggressiveness, metastasis, and fertility concerns. Surgery, sometimes combined with radioactive iodine ablation, is the primary treatment. High survival rates are reported regardless of treatment approach, but limited data hinder the standardized guidelines, highlighting the need for continued case reporting.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf149","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T08:44:21Z","timestamp":1752137061000},"source":"Crossref","is-referenced-by-count":2,"title":["Malignant Struma Ovarii: A Rare Manifestation of Ectopic Thyroid Cancer"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1577-0680","authenticated-orcid":false,"given":"Alyssia","family":"Morley","sequence":"first","affiliation":[{"name":"Department of Medicine, Department of Pathology, Advocate Lutheran General Hospital , Park Ridge, IL 60068-1143 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Kay","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Department of Pathology, Advocate Lutheran General Hospital , Park Ridge, IL 60068-1143 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Medicine, Department of Pathology, Advocate Lutheran General Hospital , Park Ridge, IL 60068-1143 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"2025071004441969200_luaf149-B1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/B978-0-323-44732-4.00026-1","article-title":"Chapter 26\u2014germ cell tumors of the ovary","author":"Medeiros","year":"2018","journal-title":"Diagnostic Gynecologic and Obstetric Pathology"},{"issue":"9","key":"2025071004441969200_luaf149-B2","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1111\/jog.14902","article-title":"Malignant struma ovarii: from case to 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A retrospective case series sharing the experience of a single institutio","volume":"303","author":"Addley","year":"2021","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"2025071004441969200_luaf149-B15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"2025071004441969200_luaf149-B16","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/jog.15545","article-title":"Current state of management of struma ovarii and preoperative imaging features: a retrospective case series study of 18 patients at a single institution","volume":"49","author":"Tamura","year":"2023","journal-title":"J Obstet Gynaecol Res"},{"issue":"4","key":"2025071004441969200_luaf149-B17","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s12022-023-09789-7","article-title":"Neoplasms in struma ovarii: a review","volume":"34","author":"Tondi Resta","year":"2023","journal-title":"Endocr Pathol"},{"issue":"9","key":"2025071004441969200_luaf149-B18","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1089\/thy.2022.0145","article-title":"Proposed risk stratification and patterns of radioactive iodine therapy in malignant struma ovarii","volume":"32","author":"Egan","year":"2022","journal-title":"Thyroid"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/8\/luaf149\/63715884\/luaf149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/8\/luaf149\/63715884\/luaf149.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T08:44:24Z","timestamp":1752137064000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luaf149\/8196033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,13]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,6,13]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luaf149","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,6,13]]},"article-number":"luaf149"}}