{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:33:19Z","timestamp":1792456399085,"version":"4.5.0"},"reference-count":7,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This report details a case of acarbose-induced pneumatosis cystoides intestinalis (PCI) in a 47-year-old man with type 2 diabetes mellitus. The patient presented with a 1-month history of abdominal pain, bloating, and intermittent diarrhea, symptoms that developed after initiating acarbose, an \u03b1-glucosidase inhibitor, for diabetes management. Abdominal computed tomography (CT) revealed characteristic features of PCI, including gas-filled cysts within the right colonic wall and free intraperitoneal gas. Notably, laboratory investigations showed no signs of infection, and other findings were unremarkable. Following the discontinuation of acarbose, initiation of a fasting regimen, and short-term metronidazole, the patient's symptoms significantly improved. His blood glucose levels were subsequently managed with repaglinide. A follow-up CT scan 2 months later confirmed the complete resolution of intramural air. This case highlights PCI as a rare but important complication associated with \u03b1-glucosidase inhibitors. Prompt recognition, withdrawal of the causative agent, and conservative management are crucial for achieving favorable outcomes. This report further underscores the critical need for increased awareness of PCI in patients receiving \u03b1-glucosidase inhibitors and emphasizes the broader importance of pharmacovigilance in identifying rare adverse drug reactions. Further research is warranted to elucidate the precise causal relationship and to explore potential preventive strategies.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf199","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:07:07Z","timestamp":1758701227000},"source":"Crossref","is-referenced-by-count":3,"title":["Acarbose-Induced Pneumatosis Cystoides Intestinalis"],"prefix":"10.1210","volume":"3","author":[{"given":"Ying","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Geriatrics, First Affiliated Hospital of Sun Yat-sen University , Guangzhou, Guangdong 510080 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, First Affiliated Hospital of Sun Yat-sen University , Guangzhou, Guangdong 510080 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital of Sun Yat-sen University , Guangzhou, Guangdong 510080 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, First Affiliated Hospital of Sun Yat-sen University , Guangzhou, Guangdong 510080 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2564-9132","authenticated-orcid":false,"given":"Lei","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, First Affiliated Hospital of Sun Yat-sen University , Guangzhou, Guangdong 510080 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"issue":"8","key":"2025092404070438400_luaf199-B1","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1056\/NEJMicm1013439","article-title":"Images in clinical medicine. Pneumatosis cystoides intestinalis","volume":"365","author":"Wu","year":"2011","journal-title":"N Engl J Med"},{"issue":"7","key":"2025092404070438400_luaf199-B2","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/ajg.2017.88","article-title":"Pneumatosis cystoides coli related to acarbose treatment","volume":"112","author":"Liao","year":"2017","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"2025092404070438400_luaf199-B3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12876-019-1087-9","article-title":"Pneumatosis cystoides intestinalis: a case report and literature review","volume":"19","author":"Ling","year":"2019","journal-title":"BMC Gastroenterol"},{"issue":"4","key":"2025092404070438400_luaf199-B4","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.transproceed.2021.02.006","article-title":"Pneumatosis Intestinalis after living donor lung transplantation associated with alpha-glucosidase inhibitor treatment: a case report","volume":"53","author":"Otsuka","year":"2021","journal-title":"Transplant Proc"},{"issue":"9","key":"2025092404070438400_luaf199-B5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/jgh3.12802","article-title":"Case of pneumatosis cystoides intestinalis with intra-abdominal free air developed during treatment with voglibose","volume":"6","author":"Hisanaga","year":"2022","journal-title":"JGH Open"},{"issue":"2","key":"2025092404070438400_luaf199-B6","doi-asserted-by":"crossref","first-page":"366","DOI":"10.2337\/diacare.22.2.366a","article-title":"Pneumatosis cystoides intestinalis after treatment with an alpha-glucosidase inhibitor","volume":"22","author":"Hayakawa","year":"1999","journal-title":"Diabetes Care"},{"issue":"3","key":"2025092404070438400_luaf199-B7","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1148\/radiol.2019182186","article-title":"Pneumatosis cystoides intestinalis secondary to use of an alpha-glucosidase inhibitor","volume":"290","author":"Lin","year":"2019","journal-title":"Radiology"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/10\/luaf199\/64358369\/luaf199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/10\/luaf199\/64358369\/luaf199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:07:08Z","timestamp":1758701228000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luaf199\/8262671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,8,19]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luaf199","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,8,19]]},"article-number":"luaf199"}}