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Patients with PPD may have a higher risk of fractures resulting from secondary osteoporosis, joint instability, and skeletal weakness. Because PPD is a rare condition with limited specific treatment guidelines, antifracture therapies that are commonly used for osteoporosis and other bone dysplasias may be considered, although these have never been tested in PPD itself. In this context, romosozumab, a monoclonal antibody primarily used in the treatment of postmenopausal osteoporosis, could represent a valid option for initiating a sequential antifracture therapy in patients affected by PDD with very low bone mineral density aiming to potentially reduce fracture risk as described in the present case report.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf203","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T12:00:21Z","timestamp":1755172821000},"source":"Crossref","is-referenced-by-count":0,"title":["Treatment With Romosozumab In Progressive Pseudorheumatoid Dysplasia"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3202-3300","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Bisceglia","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria , Bologna 40138 ,","place":["Italy"]},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna , Bologna 40138 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Scarano","sequence":"additional","affiliation":[{"name":"Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna 40138 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Piazza","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria , Bologna 40138 ,","place":["Italy"]},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna , Bologna 40138 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2242-6734","authenticated-orcid":false,"given":"Alessandra","family":"Gambineri","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria , Bologna 40138 ,","place":["Italy"]},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna , Bologna 40138 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4182-3110","authenticated-orcid":false,"given":"Uberto","family":"Pagotto","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria , Bologna 40138 ,","place":["Italy"]},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna , Bologna 40138 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-2070","authenticated-orcid":false,"given":"Guido","family":"Zavatta","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria , Bologna 40138 ,","place":["Italy"]},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna , Bologna 40138 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"issue":"4","key":"2025091922223303100_luaf203-B1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1302\/0301-620X.64B4.6807993","article-title":"Spondylo-epiphysial dysplasia tarda with progressive arthropathy. 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