{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:09:46Z","timestamp":1760058586193,"version":"build-2065373602"},"reference-count":12,"publisher":"The Endocrine Society","issue":"11","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cushing disease is caused by excess ACTH secretion by a pituitary adenoma leading to hypercortisolism. Cyclic Cushing syndrome, in which periods of cortisol excess are interspersed by periods of normal or low values, poses a challenge to diagnostic testing and postoperative monitoring. We present a 26-year-old woman with cyclic Cushing syndrome who achieved apparent biochemical remission after transsphenoidal resection of an ACTH-producing pituitary tumor, confirmed on pathology. Despite initial clinical improvement, she later experienced recurring symptoms. Biochemical evidence of hypercortisolism was documented, but 1 month later morning serum cortisol was undetectable. A desmopressin stimulation test (DesST) produced a rise in ACTH and cortisol, indicating likely residual tumor tissue. After repeat surgery, pathology again confirmed an ACTH-secreting tumor. Postoperatively, ACTH and cortisol levels were again low, but a repeat DesST was now negative, suggesting successful resection of the residual tumor, and she remains in remission 3 years later. This case describes the unique utility of the DesST to detect a pituitary corticotroph tumor in cyclic Cushing disease during periods of low disease activity. It also highlights the potential role of the DesST in postoperative monitoring.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf222","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T05:30:37Z","timestamp":1759210237000},"source":"Crossref","is-referenced-by-count":0,"title":["Using the Desmopressin Stimulation Test to Assess for Residual Tumor in Cushing Disease With Cyclic Hypercortisolism"],"prefix":"10.1210","volume":"3","author":[{"given":"Brielle M","family":"Brown","sequence":"first","affiliation":[{"name":"Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Drake","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology & Precision Medicine, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square , London EC1M 6BQ ,","place":["UK"]},{"name":"Department of Endocrinology, St Bartholomew's Hospital, Barts Health , London EC1A 7BE ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5817-9232","authenticated-orcid":false,"given":"Raven","family":"McGlotten","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0534-8025","authenticated-orcid":false,"given":"Lynnette K","family":"Nieman","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, MD 20892 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stimulation test in establishing the source of ACTH secretion in ACTH-dependent Cushing's syndrome","volume":"68","author":"Qiao","year":"2021","journal-title":"Endocr J"},{"issue":"5","key":"2025100913162691000_luaf222-B9","doi-asserted-by":"crossref","first-page":"R201","DOI":"10.1530\/EJE-18-0007","article-title":"DIAGNOSIS OF ENDOCRINE DISEASE: the role of the desmopressin test in the diagnosis and follow-up of Cushing's syndrome","volume":"178","author":"Vassiliadi","year":"2018","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2025100913162691000_luaf222-B10","first-page":"176","article-title":"A combined test using desmopressin and corticotropin-releasing hormone in the differential diagnosis of Cushing's syndrome","volume":"82","author":"Newell-Price","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2025100913162691000_luaf222-B11","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1210\/jc.2008-2234","article-title":"A combined 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