{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:22:06Z","timestamp":1784859726462,"version":"3.55.0"},"reference-count":14,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Silent lactotroph pituitary adenomas are rare tumors that clinically resemble nonfunctioning macroadenomas but are identified histologically by prolactin immunoreactivity. We report a 29-year-old woman with progressive visual loss caused by a large sella\u2013suprasellar mass compressing the optic chiasm and invading the cavernous sinus. Initial endocrine evaluation was unremarkable, and magnetic resonance imaging (MRI) suggested a nonfunctioning adenoma. She underwent urgent surgical decompression, and histology confirmed a sparsely granulated lactotroph adenoma. Despite significant residual tumor on postoperative MRI, dopamine agonist therapy was not initiated due to absent dopamine receptor type 2 staining and patient-specific factors. Retrospective imaging review revealed atypical features, including heterogeneous T2-weighted signal, mixed cystic-solid morphology, and fluid-attenuated inversion recovery\u2013T2 mismatch. This is potentially indicative of a silent subtype. This case underscores the diagnostic challenges posed by silent lactotroph adenomas and highlights the role of detailed imaging interpretation, histopathological analysis, and multidisciplinary evaluation in guiding management, especially in the absence of standardized treatment protocols for residual or recurrent disease.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf241","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T11:57:29Z","timestamp":1757678249000},"source":"Crossref","is-referenced-by-count":1,"title":["Challenges in the Management of Silent Lactotroph Pituitary Adenoma"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1897-5762","authenticated-orcid":false,"given":"Melissa Hui Ting","family":"Leong","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, National University Hospital, National University Health System , 119074","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette Li Yi","family":"Ang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, National University Hospital, National University Health System , 119074","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Diong Weng","family":"Nga","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, National University Hospital, National University Health System , 119074","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-3175","authenticated-orcid":false,"given":"Char Loo","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pathology, National University Hospital, National University Health System , 119074","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn Yen Ling","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Neuroimaging, Department of Diagnostic Imaging, National University Hospital, National University Health System , 119074","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3673-1695","authenticated-orcid":false,"given":"Doddabele Srinivasa","family":"Deepak","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, National University Hospital, National University Health System , 119074","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"issue":"7","key":"2025102406194219800_luaf241-B1","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1210\/jc.2018-00688","article-title":"Clinical 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