{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:57:35Z","timestamp":1761746255403,"version":"build-2065373602"},"reference-count":29,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Androgen-secreting adrenal adenomas are an exceptionally rare cause of hyperandrogenism, particularly in postmenopausal women. Hirsutism is a frequent clinical manifestation and warrants a comprehensive evaluation to distinguish between ovarian and adrenal sources. We present the case of a postmenopausal woman with a history of progressive hirsutism and virilization. Biochemical evaluation revealed elevated dehydroepiandrosterone sulfate (DHEAS) and total testosterone. Pelvic lesions were ruled out but abdominopelvic tomography revealed a 41\u202f\u00d7 30 mm left adrenal mass. The remaining hormonal profile was unremarkable. The patient underwent left adrenalectomy, with immunohistopathological analysis confirming an adrenal adenoma. Postoperatively, her androgen levels significantly decreased, accompanied by clinical improvement in hirsutism. Although the vast majority of hyperandrogenic states in postmenopausal women are secondary to ovarian pathology, adrenal etiologies must be ruled out. Androgen-producing adrenal adenomas represent a rare cause of hyperandrogenism, and this case contributes further evidence regarding the clinical and biochemical behavior of these benign lesions.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf250","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:04:57Z","timestamp":1758801897000},"source":"Crossref","is-referenced-by-count":0,"title":["Androgen-Secreting Adrenal Adenoma in a Postmenopausal Woman as a Cause of Hirsutism"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1868-7766","authenticated-orcid":false,"given":"Laura Natalia","family":"Berm\u00fadez-Silva","sequence":"first","affiliation":[{"name":"Unidad de Endocrinolog\u00eda, Hospital Universitario Nacional , 111711 Bogot\u00e1 ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3000-2440","authenticated-orcid":false,"given":"Julieth Daniela","family":"Buell-Acosta","sequence":"additional","affiliation":[{"name":"Unidad de Endocrinolog\u00eda, Hospital Universitario Nacional , 111711 Bogot\u00e1 ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3688-0954","authenticated-orcid":false,"given":"Luz Andrea","family":"Le\u00f3n-C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Unidad de Endocrinolog\u00eda, Hospital Universitario Nacional , 111711 Bogot\u00e1 ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3709-3568","authenticated-orcid":false,"given":"Jhon Jairo","family":"Peralta-Franco","sequence":"additional","affiliation":[{"name":"Unidad de Endocrinolog\u00eda, Hospital Universitario Nacional , 111711 Bogot\u00e1 ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"2025102906502619800_luaf250-B1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejogrb.2021.03.033","article-title":"Prevalence of at-risk hyperandrogenism by age and race\/ethnicity among females in the United States using NHANES III","volume":"260","author":"Dubey","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"5","key":"2025102906502619800_luaf250-B2","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1210\/clinem\/dgac673","article-title":"Approach to investigation of hyperandrogenism in a postmenopausal woman","volume":"108","author":"Hirschberg","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2025102906502619800_luaf250-B3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/13697137.2024.2423874","article-title":"Hyperandrogenism after menopause: diagnostic evaluation","volume":"28","author":"Fux-Otta","year":"2025","journal-title":"Climacteric J Int Menopause Soc"},{"issue":"1","key":"2025102906502619800_luaf250-B4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s12905-022-01879-8","article-title":"Postmenopausal hyperandrogenism due to an ovarian sex cord-stromal tumour causing elevated dehydroepiandrosterone sulphate: a case report","volume":"22","author":"Sumanatilleke","year":"2022","journal-title":"BMC Womens Health"},{"issue":"2","key":"2025102906502619800_luaf250-B5","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4158\/EP.7.2.120","article-title":"American Association of Clinical Endocrinologists medical guidelines for the clinical practice for the diagnosis and treatment of hyperandrogenic disorders","volume":"7","author":"Goodman","year":"2001","journal-title":"Endocr Pract"},{"issue":"6","key":"2025102906502619800_luaf250-B6","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/gme.0b013e31823fe274","article-title":"Menopausal transition stage-specific changes in circulating adrenal androgens","volume":"19","author":"McConnell","year":"2012","journal-title":"Menopause N. Y. N"},{"issue":"5","key":"2025102906502619800_luaf250-B7","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/s41574-020-0336-x","article-title":"11-Oxygenated androgens in health and disease","volume":"16","author":"Turcu","year":"2020","journal-title":"Nat Rev Endocrinol"},{"issue":"8","key":"2025102906502619800_luaf250-B8","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1007\/s40618-023-02297-9","article-title":"Postmenopausal onset of androgen excess: a diagnostic and therapeutic algorithm based on extensive clinical experience","volume":"47","author":"Luque-Ram\u00edrez","year":"2024","journal-title":"J Endocrinol Invest"},{"key":"2025102906502619800_luaf250-B9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000494909","article-title":"Androgens in menopausal women: not only polycystic ovary syndrome","volume":"53","author":"Kostakis","year":"2019","journal-title":"Front Horm Res"},{"issue":"3","key":"2025102906502619800_luaf250-B10","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1210\/jc.2017-02426","article-title":"Causes, patterns, and severity of androgen excess in 1205 consecutively recruited women","volume":"103","author":"Elhassan","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2025102906502619800_luaf250-B11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1124\/jpet.114.219550","article-title":"Regulation of human 3\u03b2-hydroxysteroid dehydrogenase type 2 by adrenal corticosteroids and product-feedback by androstenedione in human adrenarche","volume":"352","author":"Thomas","year":"2015","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"2025102906502619800_luaf250-B12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12902-019-0342-y","article-title":"A rare case of pure testosterone-secreting adrenal adenoma in a postmenopausal elderly woman","volume":"19","author":"Zhou","year":"2019","journal-title":"BMC Endocr Disord"},{"key":"2025102906502619800_luaf250-B13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.steroids.2018.09.001","article-title":"Estimating testosterone concentrations in adolescent girls: comparison of two direct immunoassays to liquid chromatography-tandem mass spectrometry","volume":"140","author":"McCartney","year":"2018","journal-title":"Steroids"},{"issue":"5 Suppl 1","key":"2025102906502619800_luaf250-B14","first-page":"S241","article-title":"The evaluation and treatment of androgen excess","volume":"86","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2006","journal-title":"Fertil Steril"},{"issue":"1","key":"2025102906502619800_luaf250-B15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ecl.2020.12.002","article-title":"Postmenopausal hyperandrogenism: evaluation and treatment strategies","volume":"50","author":"Zaman","year":"2021","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"2","key":"2025102906502619800_luaf250-B16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijwd.2015.04.003","article-title":"Endocrine evaluation of hirsutism","volume":"1","author":"Mihailidis","year":"2015","journal-title":"Int J Womens Dermatol"},{"key":"2025102906502619800_luaf250-B17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000494905","article-title":"Hyperandrogenism and Adrenocortical Tumors","volume":"53","author":"Di Dalmazi","year":"2019","journal-title":"Front Horm Res"},{"issue":"5","key":"2025102906502619800_luaf250-B18","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1530\/EJE-08-0324","article-title":"Sex steroids in androgen-secreting adrenocortical tumors: clinical and hormonal features in comparison with non-tumoral causes of androgen excess","volume":"159","author":"d\u2019Alva","year":"2008","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"2025102906502619800_luaf250-B19","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1210\/jc.2002-020922","article-title":"The value of the low-dose dexamethasone suppression test in the differential diagnosis of hyperandrogenism in women","volume":"88","author":"Kaltsas","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2025102906502619800_luaf250-B20","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1080\/09513590.2021.1897099","article-title":"Dexamethasone suppression test versus selective ovarian and adrenal vein catheterization in identifying virilizing tumors in postmenopausal hyperandrogenism\u2014a systematic review and meta-analysis","volume":"37","author":"Tng","year":"2021","journal-title":"Gynecol Endocrinol"},{"issue":"5","key":"2025102906502619800_luaf250-B21","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1530\/EJE-11-0542","article-title":"Impact of clinical, hormonal, radiological, and immunohistochemical studies on the diagnosis of postmenopausal hyperandrogenism","volume":"165","author":"Sarfati","year":"2011","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"2025102906502619800_luaf250-B22","doi-asserted-by":"crossref","first-page":"385","DOI":"10.5603\/ep.100278","article-title":"Recent guidelines for diagnostic and therapeutic management of accidentally detected adrenal tumours (incidentaloma) in adults","volume":"75","author":"Janiak","year":"2024","journal-title":"Endokrynol Pol"},{"key":"2025102906502619800_luaf250-B23","doi-asserted-by":"crossref","first-page":"797021","DOI":"10.3389\/fendo.2022.797021","article-title":"Recent advances in the clinical application of adrenal vein sampling","volume":"13","author":"Zhong","year":"2022","journal-title":"Front. Endocrinol"},{"key":"2025102906502619800_luaf250-B24","doi-asserted-by":"crossref","first-page":"1138114","DOI":"10.3389\/fendo.2023.1138114","article-title":"Pure androgen-secreting adrenal tumor (PASAT): a rare case report of bilateral PASATs and a systematic review","volume":"14","author":"Liao","year":"2023","journal-title":"Front Endocrinol"},{"key":"2025102906502619800_luaf250-B25","doi-asserted-by":"crossref","first-page":"1369582","DOI":"10.3389\/fendo.2024.1369582","article-title":"The influence of cortisol co-secretion on clinical characteristics and postoperative outcomes in unilateral primary aldosteronism","volume":"15","author":"Jiang","year":"2024","journal-title":"Front Endocrinol"},{"issue":"2","key":"2025102906502619800_luaf250-B26","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-16-0467","article-title":"Management of adrenal incidentalomas: European Society of Endocrinology clinical practice guideline in collaboration with the European network for the study of adrenal tumors","volume":"175","author":"Fassnacht","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"2025102906502619800_luaf250-B27","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11154-025-09945-w","article-title":"The differential diagnosis of adrenocortical tumors: systematic review of Ki-67 and IGF2 and meta-analysis of Ki-67","volume":"26","author":"Oliveira","year":"2025","journal-title":"Rev Endocr Metab Disord"},{"issue":"1","key":"2025102906502619800_luaf250-B28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13000-024-01496-z","article-title":"Diagnostic and prognostic assessments of adrenocortical carcinomas by pathological features, immunohistochemical markers and reticular histochemistry staining","volume":"19","author":"Gan","year":"2024","journal-title":"Diagn Pathol"},{"issue":"3","key":"2025102906502619800_luaf250-B29","doi-asserted-by":"crossref","first-page":"R131","DOI":"10.1530\/ERC-17-0361","article-title":"Genetics of tumors of the adrenal cortex","volume":"25","author":"Bonnet-Serrano","year":"2018","journal-title":"Endocr Relat Cancer"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/12\/luaf250\/65022275\/luaf250.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/3\/12\/luaf250\/65022275\/luaf250.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T10:50:36Z","timestamp":1761735036000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luaf250\/8305614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,27]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,10,27]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luaf250","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,10,27]]},"article-number":"luaf250"}}