{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:34:42Z","timestamp":1792712082147,"version":"4.5.0"},"reference-count":30,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Severe hypertriglyceridemia (HTG) during pregnancy is a rare but serious condition associated with an increased risk of maternal and fetal complications. We report the case of a 36-year-old woman diagnosed with severe HTG at 28 weeks of gestation, with triglyceride (TG) levels of 2184\u2005mg\/dL (SI: 24.68\u2005mmol\/L) (reference range, 26.50-150 mg\/dL [SI: 0.30-1.69\u2005mmol\/L]). Despite dietary intervention and \u03c9-3 supplementation, levels continued to rise, requiring hospitalization and treatment with intravenous insulin. Due to refractory HTG, plasmapheresis was initiated at 33 weeks, with significant lipid reduction. At 34 weeks, the patient underwent an emergency cesarean delivery due to preterm labor. This case underscores the challenges of managing severe HTG in pregnancy and highlights the importance of early, multidisciplinary intervention. Further research is needed to refine treatment strategies and establish standardized guidelines for this high-risk population.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf253","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:45:44Z","timestamp":1762649144000},"source":"Crossref","is-referenced-by-count":1,"title":["Severe Hypertriglyceridemia in Pregnancy: Clinical Approach and Management Strategies"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8811-3080","authenticated-orcid":false,"given":"Aina","family":"Ravent\u00f3s","sequence":"first","affiliation":[{"name":"Endocrinology and Nutrition Service, Hospital Germans Trias i Pujol , 08916 Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Velasco","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Service, Hospital Germans Trias i Pujol , 08916 Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anal\u00eda","family":"Ramos","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Hospital Germans Trias i Pujol , 08916 Badalona ,","place":["Spain"]},{"name":"Germans Trias i Pujol Research Institute , 08916 Badalona ,","place":["Spain"]},{"name":"Department of Medicine, Autonomous University of Barcelona , 08193 Bellaterra ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Alonso","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Hospital Germans Trias i Pujol , 08916 Badalona ,","place":["Spain"]},{"name":"Germans Trias i Pujol Research Institute , 08916 Badalona ,","place":["Spain"]},{"name":"Department of Medicine, Autonomous University of Barcelona , 08193 Bellaterra ,","place":["Spain"]},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III , 08041 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6744-7195","authenticated-orcid":false,"given":"Manel","family":"Puig-Domingo","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Hospital Germans Trias i Pujol , 08916 Badalona ,","place":["Spain"]},{"name":"Germans Trias i Pujol Research Institute , 08916 Badalona ,","place":["Spain"]},{"name":"Department of Medicine, Autonomous University of Barcelona , 08193 Bellaterra ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-4201","authenticated-orcid":false,"given":"Berta","family":"Soldevila","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Hospital Germans Trias i Pujol , 08916 Badalona ,","place":["Spain"]},{"name":"Germans Trias i Pujol Research Institute , 08916 Badalona ,","place":["Spain"]},{"name":"Department of Medicine, Autonomous University of Barcelona , 08193 Bellaterra ,","place":["Spain"]},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III , 08041 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"issue":"6","key":"2025110819453682900_luaf253-B1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.2217\/clp.10.64","article-title":"Maternal lipid metabolism during normal pregnancy and its implications for fetal development","volume":"5","author":"Herrera","year":"2010","journal-title":"Clin Lipidol"},{"issue":"4","key":"2025110819453682900_luaf253-B2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1177\/1753495X15594082","article-title":"Severe gestational hypertriglyceridemia: a practical approach for clinicians","volume":"8","author":"Wong","year":"2015","journal-title":"Obstet Med"},{"issue":"24","key":"2025110819453682900_luaf253-B3","doi-asserted-by":"crossref","first-page":"e285","DOI":"10.1016\/j.jacc.2018.11.003","article-title":"2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"73","author":"Grundy","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"2025110819453682900_luaf253-B4","first-page":"41","article-title":"Dyslipemias and pregnancy, an update","volume":"33","author":"Mauri","year":"2021","journal-title":"Clin Investig Arterioscler"},{"issue":"6","key":"2025110819453682900_luaf253-B5","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jacl.2015.09.002","article-title":"National Lipid Association recommendations for patient-centered management of dyslipidemia. 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