{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T10:06:38Z","timestamp":1766052398274,"version":"3.48.0"},"reference-count":10,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 59-year-old man presented for further evaluation of end-stage renal failure accompanied by hypercalcemia. For the past 10 years, his serum calcium levels had been above 10\u2005mg\/dL (SI: 2.49\u2005mmol\/L) (reference range, 8.7-10.1\u2005mg\/dL [SI: 2.17-2.52\u2005mmol\/L]) and he had experienced lower back pain and kyphosis of the thoracic spine. On admission, serum creatinine was 6.4\u2005mg\/dL (SI: 565.8\u2005\u03bcmol\/L) (reference range, 0.6-1.1\u2005mg\/dL [SI: 53-97\u2005\u03bcmol\/L]), but serum calcium was elevated 10.3\u2005mg\/dL (SI: 2.56\u2005mmol\/L) and intact PTH was significantly elevated 2837\u2005pg\/mL (SI: 301.0\u2005pmol\/L) (reference range, 10-65\u2005pg\/mL [SI:1.06-6.90\u2005pmol\/L]). Skull X-rays showed the salt and pepper sign and lumbar spine X-rays revealed the rugger jersey sign. A biopsy of the right ilium was performed. Cortical bone showed thinning associated with porosity, cancellous bone showed islanding due to bone loss, and the bone marrow had a high fat content. Some vigorous bone formation by osteoblasts was observed, but osteoclast-mediated bone resorption was predominant, suggesting osteoporosis with severe bone loss. Primary hyperparathyroidism was suspected as the underlying condition, so parathyroidectomy was performed. This case is a rare example of late diagnosis of primary hyperparathyroidism in a patient with end-stage renal failure and severe bone lesions.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf294","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:04:37Z","timestamp":1762952677000},"source":"Crossref","is-referenced-by-count":0,"title":["Morphometric Analysis of Bone Lesions in a Patient With End-stage Renal Failure Due to Primary Hyperparathyroidism"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1126-8416","authenticated-orcid":false,"given":"Shoya","family":"Taniguchi","sequence":"first","affiliation":[{"name":"Nephrology Center, Toranomon Hospital Kajigaya , Kanagawa 213-8587 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Suwabe","sequence":"additional","affiliation":[{"name":"Nephrology Center, Toranomon Hospital Kajigaya , Kanagawa 213-8587 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Pathology, Toranomon Hospital , Tokyo 105-8470 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Yamanouchi","sequence":"additional","affiliation":[{"name":"Nephrology Center, Toranomon Hospital Kajigaya , Kanagawa 213-8587 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-4094","authenticated-orcid":false,"given":"Naoki","family":"Sawa","sequence":"additional","affiliation":[{"name":"Nephrology Center, Toranomon Hospital Kajigaya , Kanagawa 213-8587 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Ubara","sequence":"additional","affiliation":[{"name":"Nephrology Center, Toranomon Hospital Kajigaya , Kanagawa 213-8587 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"issue":"1","key":"2025121805025730300_luaf294-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00198-016-3716-2","article-title":"Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. 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