{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:05:01Z","timestamp":1770149101396,"version":"3.49.0"},"reference-count":15,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Amiodarone is known to cause thyroid dysfunction, due to both direct cytotoxicity and high iodine content. Due to its lipophilic properties, amiodarone gets stored in the adipose tissue and may induce delayed amiodarone-induced thyrotoxicosis (AIT), months after discontinuation. We present the case of a 60-year-old man admitted with new-onset atrial fibrillation. He had a history of ventricular tachycardia, treated with amiodarone that was discontinued 14 months earlier. On admission, thyrotropin was undetectable, with markedly elevated free thyroxine and total triiodothyronine. He had no previous history of thyroid dysfunction or recent exposure to iodinated contrast. Additional history revealed that the patient had been taking tirzepatide 10\u2005mg weekly resulting in a 54-kg weight loss over the previous 12 months. With this information, a spot urine iodine\/creatinine (Cr) was measured and found to be significantly increased at 2323 \u00b5g\/g Cr (SI: 2075\u2005\u00b5mol\/mol Cr) (normal reference range &amp;lt;584 \u00b5g\/g Cr, [SI: &amp;lt;521 \u00b5mol\/mol Cr]). He was treated with prednisone and methimazole with eventual resolution of hyperthyroidism. Delayed AIT should be considered in the differential diagnosis of new-onset thyrotoxicosis in patients previously treated with amiodarone who experience significant weight loss.<\/jats:p>","DOI":"10.1210\/jcemcr\/luaf313","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T13:17:48Z","timestamp":1764854268000},"source":"Crossref","is-referenced-by-count":1,"title":["Delayed-Onset Amiodarone Induced Thyrotoxicosis After Glucagon-Like Peptide-1 Agonist\u2013Related Weight Loss"],"prefix":"10.1210","volume":"4","author":[{"given":"Meghan L","family":"Black","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Mayo Clinic Florida , Jacksonville, FL 32224 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine G","family":"Coyle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Mayo Clinic Florida , Jacksonville, FL 32224 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor J","family":"Bernet","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Mayo Clinic Florida , Jacksonville, FL 32224 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J","family":"McLeod","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Florida , Jacksonville, FL 32224 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9024-6626","authenticated-orcid":false,"given":"Ana-Maria","family":"Chindris","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Mayo Clinic Florida , Jacksonville, FL 32224 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"2026011205371605400_luaf313-B1","first-page":"2189","article-title":"Amiodarone: guidelines for use and monitoring","volume":"68","author":"Siddoway","year":"2003","journal-title":"Am Fam Physician"},{"issue":"7","key":"2026011205371605400_luaf313-B2","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.amjmed.2004.11.028","article-title":"Amiodarone and the thyroid","volume":"118","author":"Basaria","year":"2005","journal-title":"Am J Med"},{"issue":"2","key":"2026011205371605400_luaf313-B3","first-page":"240","article-title":"The effects of amiodarone on the thyroid","volume":"22","author":"Martino","year":"2001","journal-title":"Endocr Rev"},{"issue":"12","key":"2026011205371605400_luaf313-B4","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1253\/circj.CJ-13-0220","article-title":"Amiodarone-induced thyrotoxicosis late after amiodarone withdrawal","volume":"77","author":"Yagishita","year":"2013","journal-title":"Circ J"},{"issue":"11","key":"2026011205371605400_luaf313-B5","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/j.1552-4604.1991.tb03673.x","article-title":"Pharmacology and pharmacokinetics of amiodarone","volume":"31","author":"Freedman","year":"1991","journal-title":"J Clin Pharmacol"},{"issue":"2","key":"2026011205371605400_luaf313-B6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2165\/00003088-198409020-00002","article-title":"Clinical pharmacokinetics of amiodarone","volume":"9","author":"Latini","year":"1984","journal-title":"Clin Pharmacokinet"},{"issue":"5","key":"2026011205371605400_luaf313-B7","first-page":"e85123","article-title":"Dual Glucagon-Like Peptide-1 (GLP-1) and Glucose-Dependent Insulinotropic Polypeptide (GIP) receptor agonist-associated thyroiditis: a case report of thyroid dysfunction following tirzepatide use","volume":"17","author":"Humaida","year":"2025","journal-title":"Cureus"},{"issue":"1-4","key":"2026011205371605400_luaf313-B8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000180696","article-title":"Amiodarone: a common source of iodine-induced thyrotoxicosis","volume":"26","author":"Martino","year":"1987","journal-title":"Horm Res"},{"issue":"7","key":"2026011205371605400_luaf313-B9","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1001\/archinte.1993.00410070068010","article-title":"Thyrotoxicosis followed by hypothyroidism in patients treated with amiodarone. 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