{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:17:55Z","timestamp":1771492675930,"version":"3.50.1"},"reference-count":9,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":42,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report an extremely rare case of hypopharyngeal metastasis with anaplastic transformation (anaplastic thyroid carcinoma) originating from papillary thyroid carcinoma, demonstrating successful tumor control using minimally invasive transoral surgery combined with targeted therapy. A 78-year-old man with a history of papillary thyroid carcinoma treated with total thyroidectomy and radioactive iodine 10 years earlier presented with sore throat and difficulty swallowing. Fiberoptic examination revealed a 25-mm mass on the posterior hypopharyngeal wall causing airway compromise, necessitating an emergency tracheotomy. Biopsy confirmed hypopharyngeal metastasis with anaplastic thyroid carcinoma. Given his comorbidities (chronic leukemia, severe pulmonary arterial hypertension), he underwent transoral videolaryngoscopic surgery to achieve local tumor control while preserving swallowing function. Postoperative genetic testing detected a BRAF V600E pathogenic variant, leading to treatment with encorafenib and binimetinib, initiated on postoperative day 24. Six months after surgery and targeted therapy, fiberoptic examination and contrast-enhanced computed tomography showed no evidence of recurrent disease; the tracheostomy was closed, and the patient maintained normal swallowing and quality of life. This case illustrates that a surgery-first, function-preserving approach integrated with early molecular-targeted BRAF\/MEK inhibition can achieve durable local control and maintain laryngopharyngeal function, even when anaplastic transformation occurs within a hypopharyngeal metastatic focus.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag003","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:39:23Z","timestamp":1767875963000},"source":"Crossref","is-referenced-by-count":0,"title":["Transoral videolaryngoscopic surgery for hypopharyngeal anaplastic metastasis from papillary thyroid carcinoma"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2959-248X","authenticated-orcid":false,"given":"Yuya","family":"Yokoyama","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine , Nagoya 466-8550 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1495-0376","authenticated-orcid":false,"given":"Naoki","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine , Nagoya 466-8550 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine , Nagoya 466-8550 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunao","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine , Nagoya 466-8550 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihisa","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine , Nagoya 466-8550 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michihiko","family":"Sone","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine , Nagoya 466-8550 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"issue":"6","key":"2026021903313140600_luag003-B1","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00268-012-1437-z","article-title":"Prognostic factors and treatment outcomes for anaplastic thyroid carcinoma: ATC research consortium of Japan cohort study of 677 patients","volume":"36","author":"Sugitani","year":"2012","journal-title":"World J Surg"},{"issue":"1","key":"2026021903313140600_luag003-B2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1477-7819-1-7","article-title":"Unusual metastasis of papillary thyroid carcinoma to larynx and hypopharynx: a case report","volume":"1","author":"Varghese","year":"2003","journal-title":"World J Surg Oncol"},{"issue":"12","key":"2026021903313140600_luag003-B3","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1007\/s00405-012-2149-6","article-title":"Metastasis of papillary thyroid cancer to the larynx and pharynx: unusual case report","volume":"269","author":"Hakeem","year":"2012","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"2","key":"2026021903313140600_luag003-B4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.5152\/balkanmedj.2014.13003","article-title":"Hypopharyngeal and parapharyngeal space metastasis of papillary thyroid carcinoma: a case report","volume":"31","author":"Batioglu Karaaltin","year":"2014","journal-title":"Balkan Med J"},{"issue":"1","key":"2026021903313140600_luag003-B5","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/RLU.0000000000004468","article-title":"Metastatic papillary thyroid cancer mimicking hypopharyngeal carcinoma","volume":"48","author":"Du","year":"2023","journal-title":"Clin Nucl Med"},{"issue":"2","key":"2026021903313140600_luag003-B6","first-page":"199","article-title":"Hypopharyngeal metastasis detected 15 years after surgery for papillary thyroid carcinoma: a case report","volume":"67","author":"Nemoto","year":"2022","journal-title":"Rinsho Hoshasen"},{"issue":"4","key":"2026021903313140600_luag003-B7","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.annonc.2021.12.014","article-title":"Dabrafenib plus trametinib in BRAF V600E mutant anaplastic thyroid cancer: updated analysis from the phase II ROAR basket study","volume":"33","author":"Subbiah","year":"2022","journal-title":"Ann Oncol"},{"issue":"4","key":"2026021903313140600_luag003-B8","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1089\/thy.2022.0504","article-title":"Surgery after BRAF directed therapy is associated with improved survival in BRAF V600E mutant anaplastic thyroid cancer: a single center retrospective cohort study","volume":"33","author":"Zhao","year":"2023","journal-title":"Thyroid"},{"issue":"2","key":"2026021903313140600_luag003-B9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/hed.2880160211","article-title":"Locally invasive papillary thyroid carcinoma: 1940\u20131990","volume":"16","author":"McCaffrey","year":"1994","journal-title":"Head Neck"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/4\/2\/luag003\/66988299\/luag003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/4\/2\/luag003\/66988299\/luag003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:31:40Z","timestamp":1771489900000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luag003\/8490164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,8]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luag003","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2026,1,8]]},"article-number":"luag003"}}