{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T21:22:44Z","timestamp":1773523364387,"version":"3.50.1"},"reference-count":5,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Propylthiouracil (PTU) is a commonly used antithyroid agent for the treatment of hyperthyroidism. While generally well tolerated, it has been associated with serious adverse effects, including agranulocytosis, hepatotoxicity, and, more rarely, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. We present a case of a 58-year-old woman, known for Graves disease on 5 years of PTU treatment, who developed a hypertensive emergency and progressive renal dysfunction, initially attributed to nonsteroidal anti-inflammatory drug use. Further laboratory evaluation and kidney biopsy confirmed a diagnosis of ANCA-associated vasculitis likely induced by long-term PTU treatment. PTU was discontinued, and a prednisone taper was initiated, resulting in improvement in renal function. Following PTU discontinuation, corticosteroid therapy, and blood pressure management, the patient entered a euthyroid state with improved renal function.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag009","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T12:46:01Z","timestamp":1768394761000},"source":"Crossref","is-referenced-by-count":1,"title":["A grave complication: propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis"],"prefix":"10.1210","volume":"4","author":[{"given":"Christopher","family":"Christopoulos","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Universit\u00e9 de Montr\u00e9al , Montreal, QC , Canada H3T 1J4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6092-715X","authenticated-orcid":false,"given":"Tiffany","family":"Mach","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Residency Training Program, Department of Medicine, McGill University , Montreal, QC , Canada H3A 0G4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Tardio","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, McGill University Health Centre (MUHC) , Montreal, QC , Canada H4A 3J1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Tsoukas","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, McGill University Health Centre (MUHC) , Montreal, QC , Canada H4A 3J1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"2026022405373716200_luag009-B1","first-page":"19","article-title":"Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis and agranulocytosis in a patient with graves disease","volume":"2020","author":"Tomkins","year":"2020","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"issue":"1","key":"2026022405373716200_luag009-B2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s12882-020-01964-w","article-title":"An unusual presentation of propylthiouracil-induced anti-MPO and PR3 positive ANCA vasculitis with associated anti-GBM antibodies, IgA nephropathy and an IgG4 interstitial infiltrate: a case report","volume":"21","author":"Galante","year":"2020","journal-title":"BMC Nephrol"},{"issue":"7","key":"2026022405373716200_luag009-B3","first-page":"e27073","article-title":"Propylthiouracil-induced skin vasculitis","volume":"14","author":"Almeida","year":"2022","journal-title":"Cureus"},{"issue":"3","key":"2026022405373716200_luag009-B4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.rdc.2010.05.006","article-title":"Pathogenesis of ANCA-associated vasculitis","volume":"36","author":"Flint","year":"2010","journal-title":"Rheum Dis Clin North Am"},{"issue":"1","key":"2026022405373716200_luag009-B5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2049-6958-7-14","article-title":"Propylthiouracil-induced lupus-like or vasculitis syndrome","volume":"7","author":"Tetikkurt","year":"2012","journal-title":"Multidiscip Respir Med"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/4\/3\/luag009\/67089177\/luag009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/4\/3\/luag009\/67089177\/luag009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:37:43Z","timestamp":1771929463000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luag009\/8495829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2,23]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luag009","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,2,23]]},"article-number":"luag009"}}