{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:48:04Z","timestamp":1775083684894,"version":"3.50.1"},"reference-count":17,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pituitary adenomas occur in children quite rarely. Furthermore, pituitary abscesses are recognized as particularly rare conditions, posing considerable challenges in both diagnosis and management. We report the case of a 16-year-old patient presenting with bacterial meningoencephalitis of unknown origin, complicated by a superinfected pituitary macroadenoma. The patient initially exhibited clinical signs suggestive of meningitis, and lumbar puncture revealed a macroscopically turbid cerebrospinal fluid. Magnetic resonance imaging identified a frontobasal meningoencephalitis complicated by a suspected apoplectic pituitary adenoma measuring 30.1\u2005mm (volume: 9.0\u2005cm3). Due to the patient's neurological deterioration, urgent surgery was performed. Intraoperatively, the tumor was fibrous and partially necrotic, without evidence of abscess formation. To the best of our knowledge, only 3 cases of meningoencephalitis associated with pituitary adenomas or pituitary abscesses have been reported in the literature. This case provides a detailed account of the patient's clinical presentation, laboratory findings, and radiological results. Based on a comprehensive analysis, hematogenous spread is proposed as the most probable route of infection. We emphasize the importance of evaluating hematogenous spread of infection and tailoring treatment in similar clinical scenarios.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag032","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:48:05Z","timestamp":1769690885000},"source":"Crossref","is-referenced-by-count":0,"title":["Meningoencephalitis and secondary pituitary abscess in a 16-year-old patient with gigantism"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5444-3587","authenticated-orcid":false,"given":"Magdalena","family":"Wissa","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Medical University Graz , Graz 8010, Styria ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Strenger","sequence":"additional","affiliation":[{"name":"Division of General Pediatrics, Department of Pediatrics and Adolescent Medicine, Medical University Graz , Graz 8010, Styria ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudrun","family":"Weinhandl","sequence":"additional","affiliation":[{"name":"Division of General Pediatrics, Department of Pediatrics and Adolescent Medicine, Medical University Graz , Graz 8010, Styria ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannes","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Medical University Graz , Graz 8010, Styria ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Wolfsberger","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University Graz , Graz 8010, Styria ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9105-3519","authenticated-orcid":false,"given":"Alexander","family":"Micko","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University Graz , Graz 8010, Styria ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"issue":"1","key":"2026040117231224700_luag032-B1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1055\/s-0038-1625984","article-title":"Pediatric Pituitary Adenoma: case series, review of the literature, and a skull base treatment paradigm","volume":"79","author":"Perry","year":"2018","journal-title":"J Neurol Surg B Skull Base"},{"issue":"2","key":"2026040117231224700_luag032-B2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11102-016-0757-7","article-title":"Pituitary abscess: clinical manifestations, diagnosis and treatment of 66 cases from a large pituitary center over 23 years","volume":"20","author":"Gao","year":"2017","journal-title":"Pituitary"},{"issue":"1","key":"2026040117231224700_luag032-B3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrendo.2014.181","article-title":"Genetic mutations in sporadic pituitary adenomas\u2013what to screen for?","volume":"11","author":"Lecoq","year":"2015","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"2026040117231224700_luag032-B4","doi-asserted-by":"crossref","first-page":"517 e1","DOI":"10.1016\/j.ajem.2008.08.004","article-title":"Pituitary Adenoma apoplexy with initial presentation mimicking bacterial meningoencephalitis: a case report","volume":"27","author":"Huang","year":"2009","journal-title":"Am J Emerg Med"},{"key":"2026040117231224700_luag032-B5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.wneu.2020.02.057","article-title":"Secondary Pituitary Abscess inside Adenoma: a case report and review of literature","volume":"137","author":"Zhang","year":"2020","journal-title":"World Neurosurg"},{"issue":"1","key":"2026040117231224700_luag032-B6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13023-023-02788-1","article-title":"Pituitary abscess: a case report and systematic review of 488 cases","volume":"18","author":"Stringer","year":"2023","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"2026040117231224700_luag032-B7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1756-0500-7-9","article-title":"Acute aseptic meningitis as the initial presentation of a macroprolactinoma","volume":"7","author":"Boscolo","year":"2014","journal-title":"BMC Res Notes"},{"key":"2026040117231224700_luag032-B8","first-page":"EP847","article-title":"Meningoencephalitis as the first clinical sign of a pituitary macro adenoma: a case report","volume":"49","author":"Elmghari","year":"2017","journal-title":"Endocr. 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