{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:48:03Z","timestamp":1775083683378,"version":"3.50.1"},"reference-count":30,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients with end-stage lung disease go through an extensive screening process prior to transplant. Obesity and uncontrolled type 2 diabetes mellitus (T2DM) are unfavorable risk factors that lead to poor outcomes. We present the case of a 69-year-old man with stage IV chronic obstructive pulmonary disease (COPD) on chronic oxygen, T2DM on insulin, and class II obesity (reference range, body mass index [BMI], 35.0-39.9) who underwent pre\u2013lung transplant evaluation. He had a BMI of 38.05, surpassing the institutional transplant eligibility criteria of BMI &amp;lt;32. The patient was initiated on semaglutide for weight loss. After 6 months, the patient's BMI decreased to 30.5, losing 25\u2005kg and qualifying him for transplant. However, given substantial improvements in respiratory status, the pre\u2013lung transplant committee deferred waitlisting. After 16 months of treatment, the patient lost a total of 35.17\u2005kg, his forced vital capacity improved from 44% to 82%, and he was weaned off oxygen. Chronic hypoxia and corticosteroids make weight management challenging for COPD patients. This case demonstrates the use of semaglutide for rapid weight loss and improved respiratory function in patients with end-stage lung disease, emphasizing its emerging potential in pre\u2013lung transplant optimization.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag040","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:54:51Z","timestamp":1771505691000},"source":"Crossref","is-referenced-by-count":0,"title":["Semaglutide as a potential tool in pre\u2013lung transplant weight loss optimization"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-8216","authenticated-orcid":false,"given":"Roshaneh","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Texas Health Science Center at San Antonio , San Antonio, TX 78229 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly","family":"Keyt","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, University Health Transplant Institute, Alvarez Center for Transplantation, Hepatobiliary Surgery and Innovation, University of Texas Health Science Center at San Antonio , San Antonio, TX 78229 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6215-9418","authenticated-orcid":false,"given":"Carolina","family":"Solis-Herrera","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, University of Texas Health Science Center at San Antonio , San Antonio, TX 78229 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Escobar-Vasco","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, University of Texas Health Science Center at San Antonio , San 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