{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:56:19Z","timestamp":1777010179356,"version":"3.51.4"},"reference-count":9,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK098468"],"award-info":[{"award-number":["R01DK098468"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"J.W. Kiekeffer Foundation"},{"name":"Center for Regenerative Biotherapeutics"},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Insulinoma is the most prevalent neuroendocrine tumor of the pancreas, presenting with a spectrum of neuroglycopenic symptoms. This case report describes a 64-year-old woman with primarily postprandial hypoglycemia, resulting in altered consciousness and confusion occurring several hours after meals. Continuous glucose monitoring (CGM) was used to establish the postprandial pattern of the patient's hypoglycemia, and this facilitated the confirmatory biochemical evaluation by a single blood draw done at the time of symptoms, without performing a 72-hour fast. Imaging demonstrated an 11-mm tumor in the pancreas, which was removed and confirmed to be a well-differentiated neuroendocrine tumor on histopathology. While awaiting pancreatic surgery, the patient began taking melatonin for sleep and reported an improvement in the frequency and severity of hypoglycemia symptoms, which was supported by CGM data and a robust expression of melatonin receptors on the excised tumor. This case raises interest in the role of melatonin receptor signaling in counteracting hyperinsulinemia and corresponding hypoglycemia in patients with insulinoma.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag067","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T12:47:01Z","timestamp":1772887621000},"source":"Crossref","is-referenced-by-count":0,"title":["Melatonin improves postprandial hypoglycemia: an unusual presentation of insulinoma"],"prefix":"10.1210","volume":"4","author":[{"given":"Thanh","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine , Rochester, MN 55902 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7761-4842","authenticated-orcid":false,"given":"Aleksey","family":"Matveyenko","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine , Rochester, MN 55902 ,","place":["USA"]},{"name":"Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Mayo Clinic School of Medicine , Rochester, MN 55902 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1998-9993","authenticated-orcid":false,"given":"Galina","family":"Smushkin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, University of British Columbia , Victoria, BC V5Z 1M9 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"issue":"4","key":"2026042401331320800_luag067-B1","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1210\/jc.2008-2031","article-title":"Secular trends in the presentation and management of functioning insulinoma at the mayo clinic, 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main pancreatic islet cell types","volume":"65","author":"Zibolka","year":"2018","journal-title":"J Pineal Res"},{"issue":"1","key":"2026042401331320800_luag067-B5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00441-002-0581-4","article-title":"Mammalian melatonin receptors: molecular biology and signal transduction","volume":"309","author":"von Gall","year":"2002","journal-title":"Cell Tissue Res"},{"issue":"6","key":"2026042401331320800_luag067-B6","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.cmet.2016.04.009","article-title":"Increased melatonin signaling is a risk factor for type 2 diabetes","volume":"23","author":"Tuomi","year":"2016","journal-title":"Cell Metab"},{"issue":"1","key":"2026042401331320800_luag067-B7","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/ng.288","article-title":"Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin 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