{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:42:14Z","timestamp":1777293734861,"version":"3.51.4"},"reference-count":10,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dual ectopic secretion of adrenocorticotropic hormone (ACTH) and growth hormone-releasing hormone (GHRH) by a single neuroendocrine tumor (NET) is extremely rare. We report a 43-year-old woman presenting with acral enlargement, weight gain, hyperpigmentation, and proximal muscle weakness. Laboratory evaluation revealed elevated cortisol, ACTH, and insulin-like growth factor 1 (IGF-1), consistent with concurrent Cushing syndrome and acromegaly. Imaging demonstrated a left hilar mass, and biopsy confirmed a pulmonary NET with immunohistochemical (IHC) positivity for synaptophysin and chromogranin. Pituitary magnetic resonance imaging (MRI) showed diffuse hyperplasia, suggesting trophic stimulation rather than a primary pituitary adenoma. Surgical resection resulted in normalization of hormone levels, marked clinical improvement, and regression of pituitary enlargement. Although direct histologic confirmation of tumor-derived GHRH was unavailable, the reversible pituitary hyperplasia favors ectopic GHRH-mediated stimulation rather than primary ectopic GH secretion. IHC of the resected tumor demonstrated ACTH positivity, supporting ectopic ACTH secretion. This case highlights the importance of recognizing dual hormone\u2013secreting NETs in patients presenting with overlapping endocrine syndromes, as early detection and complete resection can lead to remission.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag092","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T12:39:34Z","timestamp":1774096774000},"source":"Crossref","is-referenced-by-count":0,"title":["A rare case of dual hormone-secreting pulmonary neuroendocrine tumor causing concurrent Cushing syndrome and acromegaly"],"prefix":"10.1210","volume":"4","author":[{"given":"Dogga","family":"Sudhakar","sequence":"first","affiliation":[{"name":"Department of Endocrinology, National Institute of Medical Sciences and Research, Nims University Rajasthan , Jaipur 303121 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1101-4543","authenticated-orcid":false,"given":"Sourav","family":"Debnath","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Nims Institute of Pharmacy, Nims University Rajasthan , Jaipur 303121 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishant","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, National Institute of Medical Sciences and Research, Nims University Rajasthan , Jaipur 303121 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveen","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, National Institute of Medical Sciences and Research, Nims University Rajasthan , Jaipur 303121 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9430-4659","authenticated-orcid":false,"given":"Mahaveer","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, National Institute of Medical Sciences and Research, Nims University Rajasthan , Jaipur 303121 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"issue":"12","key":"2026042707410213400_luag092-B1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.neo.2017.09.002","article-title":"Nothing but NET: a review of neuroendocrine tumors and carcinomas","volume":"19","author":"Oronsky","year":"2017","journal-title":"Neoplasia"},{"issue":"20","key":"2026042707410213400_luag092-B2","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.2169\/internalmedicine.55.6827","article-title":"Metastatic pancreatic neuroendocrine tumor that progressed to ectopic adrenocorticotropic hormone (ACTH) syndrome with growth hormone-releasing hormone (GHRH) production","volume":"55","author":"Tadokoro","year":"2016","journal-title":"Intern Med"},{"issue":"3","key":"2026042707410213400_luag092-B3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1530\/EJE-15-0968","article-title":"Prevalence and clinical features of the ectopic ACTH syndrome in patients with gastroenteropancreatic and thoracic neuroendocrine tumors","volume":"174","author":"Kamp","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2026042707410213400_luag092-B4","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/s13104-016-2132-1","article-title":"Acromegaly in a patient with a pulmonary neuroendocrine tumor: case report and review of current literature","volume":"9","author":"Krug","year":"2016","journal-title":"BMC Res 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infarction","volume":"64","author":"Southgate","year":"1988","journal-title":"Postgrad Med J"}],"container-title":["JCEM Case 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