{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:22:34Z","timestamp":1777645354310,"version":"3.51.4"},"reference-count":17,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Laboratory Medicine, Cliniques Universitaires Saint-Luc, UCLouvain"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Giant prolactinomas are rare pituitary tumors characterized by extremely high prolactin levels and extensive extrasellar invasion. While dopamine agonists are usually effective, they may require months to normalize prolactin. We report a 47-year-old premenopausal woman presenting with new-onset temporal epilepsy and secondary amenorrhea. Assessments revealed marked hyperprolactinemia (mean serum prolactin concentration, 3902\u2005ng\/mL [SI: 169.8\u2005nmol\/L]) (reference range, 5.0-30.0\u2005ng\/mL [SI: 0.22-1.30\u2005nmol\/L]), and an invasive 47 \u00d7 43 \u00d7 50\u2005mm adenoma extending into the right temporal lobe. After initiating cabergoline (0.25\u2005mg\/day), serum prolactin dropped to 802\u2005ng\/mL (SI: 34.9\u2005nmol\/L) within 18\u2005hours and normalized by day 4 (12.7\u2005ng\/mL [SI: 0.55\u2005nmol\/L]). Polyethylene glycol recovery excluded macroprolactinemia. Despite ultra-rapid biochemical remission, magnetic resonance imaging at 3 and 6 months revealed no tumor shrinkage despite increasing cabergoline to a maximal tolerated dose of 0.75\u2005mg\/week. The patient remained seizure free and resumed normal menses. This case illustrates a striking dissociation between hormonal sensitivity and a lack of radiological regression.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag105","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:47:25Z","timestamp":1774615645000},"source":"Crossref","is-referenced-by-count":0,"title":["Ultra-rapid prolactin normalization with cabergoline in a premenopausal woman with epilepsy and giant prolactinoma"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-3069","authenticated-orcid":false,"given":"Perrin","family":"Ngougni Pokem","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Cliniques Universitaires Saint-Luc, UCLouvain , Brussels B-1200 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2665-9455","authenticated-orcid":false,"given":"Stefan Matei","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc , Brussels B-1200 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadrien","family":"Cools","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Cliniques Universitaires Saint-Luc, UCLouvain , Brussels B-1200 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0918-637X","authenticated-orcid":false,"given":"Dominique","family":"Maiter","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc , Brussels B-1200 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5987-4376","authenticated-orcid":false,"given":"Damien","family":"Gruson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Cliniques Universitaires Saint-Luc, UCLouvain , Brussels B-1200 ,","place":["Belgium"]},{"name":"Endocrinology, Diabetes and Nutrition Research Centre, Institute for Experimental and Clinical Research, Cliniques Universitaires Saint-Luc and UCLouvain , Brussels B-1200 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"issue":"4","key":"2026042902313434200_luag105-B1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/cen.12242","article-title":"Giant prolactinomas: the therapeutic approach","volume":"79","author":"Moraes","year":"2013","journal-title":"Clin Endocrinol 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