{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:15:28Z","timestamp":1779279328316,"version":"3.51.4"},"reference-count":14,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The discovery of an adrenal incidentaloma should prompt an evaluation for the presence of malignancy and autonomous hormonal secretion. Concomitant adrenal nodule and hypercortisolism or primary aldosteronism does not inherently confirm the adrenal lesion as the source of excessive hormone. Localization studies are needed to ensure proper identification of the source of hormone oversecretion prior to consideration of surgical resection. We report a case in which a patient presented with an adrenal incidentaloma but was found through extensive hormonal testing and localization studies to have Cushing disease and primary aldosteronism, which was localized to the contralateral adrenal gland, whereas the adrenal incidentaloma that prompted the initial evaluation appeared to be nonfunctioning. Our case report highlights the importance of localizing the functioning lesion in the context of an adrenal incidentaloma.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag114","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:45:43Z","timestamp":1775043943000},"source":"Crossref","is-referenced-by-count":0,"title":["Cushing disease and unilateral primary aldosteronism confounded by a nonfunctioning contralateral adrenal incidentaloma"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8469-5633","authenticated-orcid":false,"given":"Jared","family":"Friedman","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine , Chicago, IL 60611 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2038-8589","authenticated-orcid":false,"given":"Pouya","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Malnati Brain Tumor Institute of the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine , Chicago, IL 60611 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7329-1887","authenticated-orcid":false,"given":"Wenyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine , Chicago, IL 60611 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"issue":"6","key":"2026052007565543300_luag114-B1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1210\/endrev\/bnaa008","article-title":"Adrenal incidentaloma","volume":"41","author":"Sherlock","year":"2020","journal-title":"Endocr Rev"},{"issue":"1","key":"2026052007565543300_luag114-B2","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1093\/ejendo\/lvad066","article-title":"European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European network for the study of adrenal tumors","volume":"189","author":"Fassnacht","year":"2023","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"2026052007565543300_luag114-B3","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1001\/jamasurg.2022.3544","article-title":"American association of endocrine surgeons guidelines for adrenalectomy: executive summary","volume":"157","author":"Yip","year":"2022","journal-title":"JAMA Surg"},{"key":"2026052007565543300_luag114-B4","first-page":"281","article-title":"Cushing's syndrome: epidemiology and developments in disease management","volume":"7","author":"Sharma","year":"2015","journal-title":"Clin Epidemiol"},{"issue":"5","key":"2026052007565543300_luag114-B5","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2026052007565543300_luag114-B6","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1210\/clinem\/dgaf284","article-title":"Primary aldosteronism: an endocrine society clinical practice guideline","volume":"110","author":"Adler","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2026052007565543300_luag114-B7","doi-asserted-by":"crossref","first-page":"101513","DOI":"10.1016\/j.beem.2021.101513","article-title":"New types of localization methods for adrenocorticotropic hormone-dependent Cushing's syndrome","volume":"35","author":"Senanayake","year":"2021","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"4","key":"2026052007565543300_luag114-B8","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1161\/HYPERTENSIONAHA.121.18761","article-title":"Primary Aldosteronism: where are we now? Where to from here?","volume":"79","author":"Funder","year":"2022","journal-title":"Hypertension"},{"key":"2026052007565543300_luag114-B9","first-page":"150075","article-title":"Use of plasma metanephrine to aid adrenal venous sampling in combined aldosterone and cortisol over-secretion","volume":"2015","author":"Goupil","year":"2015","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"issue":"1","key":"2026052007565543300_luag114-B10","first-page":"41","article-title":"Coexistence of cushing disease with a solitary Adrenocorticotrophic hormone-dependent adrenal adenoma","volume":"8","author":"Shakir","year":"2022","journal-title":"AACE Clin Case Rep"},{"issue":"C","key":"2026052007565543300_luag114-B11","doi-asserted-by":"crossref","first-page":"107038","DOI":"10.1016\/j.ijscr.2022.107038","article-title":"Simultaneous pituitary and adrenal adenomas in a patient with non ACTH dependent cushing syndrome; a case report with literature review","volume":"94","author":"Ahmed","year":"2022","journal-title":"Int J Surg Case Rep"},{"issue":"11","key":"2026052007565543300_luag114-B12","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.3390\/diagnostics12112772","article-title":"The entity of connshing syndrome: primary aldosteronism with autonomous cortisol secretion","volume":"12","author":"Carsote","year":"2022","journal-title":"Diagnostics (Basel)"},{"issue":"1","key":"2026052007565543300_luag114-B13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12902-019-0395-y","article-title":"Hypercortisolism and primary aldosteronism caused by bilateral adrenocortical adenomas: a case report","volume":"19","author":"Ren","year":"2019","journal-title":"BMC Endocr Disord"},{"issue":"3","key":"2026052007565543300_luag114-B14","doi-asserted-by":"crossref","first-page":"dgz136","DOI":"10.1210\/clinem\/dgz136","article-title":"Time to diagnosis in Cushing's syndrome: a meta-analysis based on 5367 patients","volume":"105","author":"Rubinstein","year":"2020","journal-title":"J Clin Endocrinol Metab"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/4\/6\/luag114\/68273576\/luag114.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/4\/6\/luag114\/68273576\/luag114.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:57:43Z","timestamp":1779278263000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luag114\/8676521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,4,29]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luag114","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,4,29]]},"article-number":"luag114"}}