{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:55:25Z","timestamp":1776851725941,"version":"3.51.2"},"reference-count":15,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Glucagon-like peptide-1 (GLP-1) receptor agonists are widely used for the management of obesity; however, respiratory complications are rarely documented. A 40-year-old person without diabetes with obesity (body mass index [BMI] 36\u2005kg\/m2) developed excessive daytime sleepiness and morning headaches four weeks after semaglutide dose escalation to 1\u2005mg per week. Arterial blood gas analysis revealed respiratory acidosis (pH 7.33 [reference range (RR): 7.35-7.45], partial pressure of arterial carbon dioxide [PaCO2] 56\u2005mmHg [RR: 35-45\u2005mmHg]) with a normal alveolar-arterial (A\u2013a) gradient. A comprehensive evaluation excluded conventional causes of hypercapnia. Overnight capnographic monitoring using transcutaneous carbon dioxide (CO2) demonstrated sustained nocturnal hypercapnia without apneic events (Apnea-Hypopnea Index [AHI] &amp;lt; 5 events\/hour), suggesting impaired central ventilatory drive rather than sleep-disordered breathing. Following semaglutide discontinuation and temporary noninvasive ventilation (NIV), symptoms resolved within 10 days. Arterial blood gas levels normalized at 3 weeks (pH 7.38, PaCO2 44\u2005mmHg). The patient remained asymptomatic at the 3-month follow-up. This case demonstrates a previously uncharacterized association between semaglutide and reversible central respiratory depression. Clinicians should remain vigilant for unexplained hypercapnia in individuals receiving GLP-1 receptor agonists, particularly following dose escalation.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag121","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:31:28Z","timestamp":1775561488000},"source":"Crossref","is-referenced-by-count":0,"title":["Unexplained hypercapnia with normal pulmonary evaluation in a patient receiving semaglutide: a diagnostic challenge"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0817-6439","authenticated-orcid":false,"given":"Sai","family":"Prasad","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, S. Nijalingappa Medical College , Bagalkote, Karnataka 587102 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aarushi","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Maulana Azad Medical College , New Delhi, Delhi 110002 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7479-4630","authenticated-orcid":false,"given":"Laxmansa C","family":"Katwa","sequence":"additional","affiliation":[{"name":"Department of Physiology, East Carolina University Brody School of Medicine , Greenville, NC 27834 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreya","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hamdard Institute of Medical Sciences and Research , New Delhi, Delhi 110062 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidhi","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, D. Y. Patil Medical College , Navi Mumbai, Maharashtra 400706 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaily","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Shri M. P. 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