{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:10:19Z","timestamp":1780384219078,"version":"3.54.1"},"reference-count":23,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pregnancy-induced Cushing syndrome (PICS) is an exceptionally rare form of adrenocorticotropin (ACTH)-independent Cushing syndrome (CS) caused by aberrant expression of luteinizing hormone (LH) and\/or human chorionic gonadotropin (hCG) receptors in adrenal cortical cells. To date, only a small number of cases have been reported, most with adrenal abnormalities on imaging. We describe a 25-year-old pregnant woman who presented at 26 weeks\u2019 gestation with new-onset hypertension and overt features of hypercortisolism, including severe acne, hirsutism, dorsocervical fat pad, and extensive violaceous striae. Biochemical evaluation confirmed severe ACTH-independent CS with markedly elevated 24-hour urinary free cortisol, elevated serum cortisol with loss of diurnal variation, elevated midnight salivary cortisol, and suppressed ACTH levels. Pituitary, adrenal, and ovarian imaging were unremarkable. The patient was successfully managed with metyrapone until delivery, with favorable maternal and neonatal outcomes. Postpartum resolution of hypercortisolism and a positive hCG stimulation test confirmed the diagnosis of PICS. This case highlights the diagnostic complexity of PICS and underscores the role of timely medical therapy and multidisciplinary management.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag134","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:33:24Z","timestamp":1777116804000},"source":"Crossref","is-referenced-by-count":0,"title":["Pregnancy-induced Cushing syndrome: diagnosis and management of a rare endocrine disorder"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7236-5354","authenticated-orcid":false,"given":"Ronit","family":"Koren","sequence":"first","affiliation":[{"name":"Department of Internal Medicine A, Shamir Medical Center (Assaf Harofeh) , Be'er Ya'akov, Zerifin 70300 ,","place":["Israel"]},{"name":"Gray Faculty of Medicine, Tel Aviv University , Tel Aviv 6997801 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrat","family":"Markus","sequence":"additional","affiliation":[{"name":"Endocrine Institute, Shamir Medical Center , Be'er Ya'akov, Zerifin 70300 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifat","family":"Wiener","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medicine, Tel Aviv University , Tel Aviv 6997801 ,","place":["Israel"]},{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology , Be'er Ya'akov, Zerifin 70300 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4923-488X","authenticated-orcid":false,"given":"Yona","family":"Greenman","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medicine, Tel Aviv University , Tel Aviv 6997801 ,","place":["Israel"]},{"name":"Institute of Endocrinology, Metabolism, Diabetes and Hypertension, Tel Aviv-Sourasky Medical Center , Tel Aviv 64239 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit","family":"Koren","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medicine, Tel Aviv University , Tel Aviv 6997801 ,","place":["Israel"]},{"name":"Endocrine Institute, Shamir Medical Center , Be'er Ya'akov, Zerifin 70300 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"issue":"2","key":"2026060202420998200_luag134-B1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s12020-016-1117-0","article-title":"Cushing\u2019s syndrome and pregnancy outcomes: a systematic review of published 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