{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:07:27Z","timestamp":1780538847219,"version":"3.54.1"},"reference-count":25,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011077","name":"SUS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011077","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cear\u00e1 Foundation"},{"name":"Scientific Development"},{"DOI":"10.13039\/501100005283","name":"FUNCAP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report the case of a 35-year-old woman with clinically and genetically confirmed multiple endocrine neoplasia type 1 (MEN1) who presented with abnormal uterine bleeding, hypermenorrhea, menstrual irregularities, and visual field defects. Hormonal evaluation revealed elevated estradiol levels, non-suppressed follicle-stimulating hormone (FSH), suppressed luteinizing hormone (LH), and mild hyperprolactinemia. Magnetic resonance imaging demonstrated a large pituitary macroadenoma. The patient underwent transsphenoidal surgery, and histopathological and immunohistochemical (IHQ) analyses confirmed a functioning gonadotroph adenoma. Postoperatively, clinical and gynecologic symptoms improved; however, residual tumor tissue showed progression on follow-up imaging. This case highlights a rare but clinically significant manifestation of MEN1-associated pituitary disease. Functioning gonadotroph adenomas may present with ovarian hyperstimulation rather than typical hypogonadism or mass-related symptoms. Recognition of this distinct biochemical and clinical profile is essential for timely diagnosis and management. Functioning gonadotroph adenomas, although rare in MEN1, should be considered in patients presenting with ovarian hyperstimulation and atypical gynecologic symptoms. Surgical resection is the mainstay of treatment, but long-term surveillance is required due to the risk of residual disease progression.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag136","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:41:12Z","timestamp":1778067672000},"source":"Crossref","is-referenced-by-count":0,"title":["Functioning gonadotroph macroadenoma associated with multiple endocrine neoplasia type 1"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4011-1583","authenticated-orcid":false,"given":"Carlos Eduardo de Melo","family":"Oliveira","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Federal University of Cear\u00e1 (UFC) , Fortaleza, Cear\u00e1 60430-160 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1147-4159","authenticated-orcid":false,"given":"Delmar Muniz Louren\u00e7o","family":"Junior","sequence":"additional","affiliation":[{"name":"Endocrine Genetics Unit, Laboratory of Cellular and Molecular Endocrinology (LIM-25), Division of Endocrinology and Metabolism, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP) , S\u00e3o Paulo 05403-010 ,","place":["Brazil"]},{"name":"Division of Endocrine Oncology (D.M.L.J.), Institute of Cancer of the State of S\u00e3o Paulo (ICESP), University of S\u00e3o Paulo School of Medicine (FMUSP) , S\u00e3o Paulo 05403-010 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8237-8098","authenticated-orcid":false,"given":"Teresa Neuma","family":"Albuquerque Gomes Nogueira","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Cear\u00e1 (UFC) , Fortaleza, Cear\u00e1 60430-160 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-0580","authenticated-orcid":false,"given":"Jos\u00e9 \u00cdtalo Soares","family":"Mota","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina, Federal University of Cear\u00e1 (UFC) , Fortaleza, Cear\u00e1 60430-160 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3861-293X","authenticated-orcid":false,"given":"Raquel","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Drug Research and Development Center (NPDM), Faculty of Medicine, Federal University of Cear\u00e1 (UFC) , Fortaleza, Cear\u00e1 60430-275 ,","place":["Brazil"]},{"name":"Pharmacogenetics Laboratory, Faculty of Medicine, Federal University of Cear\u00e1 (UFC) , Fortaleza, Cear\u00e1 60430-275 ,","place":["Brazil"]},{"name":"Latin American Network for Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED) , Santiago 8320-000 ,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1876-6410","authenticated-orcid":false,"given":"Ana Rosa Pinto","family":"Quidute","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina, Federal University of Cear\u00e1 (UFC) , Fortaleza, Cear\u00e1 60430-160 ,","place":["Brazil"]},{"name":"Department of Physiology and Pharmacology, Drug Research and Development Center (NPDM), Faculty of Medicine, Federal University of Cear\u00e1 (UFC) , Fortaleza, Cear\u00e1 60430-275 ,","place":["Brazil"]},{"name":"Pharmacogenetics Laboratory, Faculty of Medicine, Federal University of Cear\u00e1 (UFC) , Fortaleza, Cear\u00e1 60430-275 ,","place":["Brazil"]},{"name":"Department of Clinical Endocrinology and Diabetes, Faculty of 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