{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T07:06:15Z","timestamp":1779865575020,"version":"3.53.1"},"reference-count":24,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Classic adipsic vasopressin deficiency features hypotonic polyuria and absent thirst despite hypernatremia. We report a 21-year-old patient with prior resected pilocytic astrocytoma who presented dehydration and hypernatremia of 158 mEq\/L (158\u2005mmol\/L) (reference range, 135-145 mEq\/L [SI: 135-145\u2005mmol\/L]). He denied thirst and had no polyuria or polydipsia. Plasma and urinary osmolalities were 317 mOsm\/Kg (317\u2005mmol\/Kg) (reference range, 282-295 mOsm\/Kg [282-295\u2005mmol\/Kg]) and 878 mOsm\/Kg (878\u2005mmol\/Kg) (reference range, 200-1200 mOsm\/Kg [200-1200\u2005mmol\/Kg]), respectively. After prescribed oral water intake, serum sodium normalized and urinary volume remained normal. To assess osmoregulation, plasma copeptin and thirst visual scale were assessed during 3% saline infusion. Despite increases in serum sodium, the patient reported no change in thirst, confirming adipsia. Copeptin value was 3.2\u2005pmol\/L at the end of the saline infusion (reference range, 3.7-43.3\u2005pmol\/L) and 4.1\u2005pmol\/L during hypovolemic hypernatremia, both low-normal values considering hypernatremia, suggesting impaired osmolality-driven vasopressin secretion. This case illustrates a partial defect in osmoregulatory vasopressin release with maintained renal response and highlights the diagnostic utility of osmotic-stimulated copeptin measurement for functional characterization of vasopressin dynamics in rare adipsic disorders.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag140","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:07:39Z","timestamp":1777637259000},"source":"Crossref","is-referenced-by-count":0,"title":["Copeptin as a diagnostic tool in a patient with adipsia and hypernatremia"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2780-4813","authenticated-orcid":false,"given":"Paula Cond\u00e9 Lamparelli","family":"Elias","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School - University of Sao Paulo , Ribeirao Preto 14049-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Ristow","family":"de Assun\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School - University of Sao Paulo , Ribeirao Preto 14049-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Carlos","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirao Preto Medical School - University of Sao Paulo , Ribeirao Preto 14049-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4932-4623","authenticated-orcid":false,"given":"Margaret","family":"de Castro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School - University of Sao Paulo , Ribeirao Preto 14049-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucila Leico Kagohara","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ribeirao Preto Medical School - University of Sao Paulo , Ribeirao Preto 14049-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayrton Cust\u00f3dio","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School - 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