{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:59:25Z","timestamp":1780995565290,"version":"3.54.1"},"reference-count":22,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Type 1 diabetes mellitus (T1DM) is the most common form of diabetes in young people, and the prevalence of type 2 diabetes mellitus (T2DM) is increasing due to obesity. Latent autoimmune diabetes in adults (LADA) typically presents after age 30, and these patients do not require insulin during the first 6 months after diagnosis. A similar clinical profile presenting before age 30 is known as latent autoimmune diabetes in young (LADY). Maturity-onset diabetes in young (MODY) is a monogenic form of diabetes classified into 14 subtypes based on the pathogenic gene variant and systemic manifestations. We present a 22-year-old woman who was incidentally found to have diabetes at age 18 and had a positive glutamic acid decarboxylase (GAD) antibody. She received oral hypoglycemic agents for the first 4 years and recently started insulin due to poor glycemic control. Whole exome sequencing revealed a heterozygous single-base pair deletion in exon 11 of the carboxyl ester lipase (CEL) gene (chr9:g.133071542del; c.2040del; p.Val681CysfsTer23), suggestive of CEL-MODY, also known as MODY 8. Our report highlights the unusual occurrence of double diabetes (LADY and MODY) in a young woman.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag158","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:14:55Z","timestamp":1779794095000},"source":"Crossref","is-referenced-by-count":0,"title":["An unusual combination of latent autoimmune diabetes in young and maturity-onset diabetes in young"],"prefix":"10.1210","volume":"4","author":[{"given":"Aishwarya","family":"Bora","sequence":"first","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College & Hospital , Hyderabad 500038 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C V S","family":"Manasa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College & Hospital , Hyderabad 500038 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitha A V","family":"Alekya","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College & Hospital , Hyderabad 500038 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sravanthi","family":"Mashetty","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College & Hospital , Hyderabad 500038 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Guddeti","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College & Hospital , Hyderabad 500038 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9601-0320","authenticated-orcid":false,"given":"K V S","family":"Hari Kumar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College & Hospital , Hyderabad 500038 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"issue":"1","key":"2026060904160451200_luag158-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mcna.2014.08.015","article-title":"Update on diabetes classification","volume":"99","author":"Thomas","year":"2015","journal-title":"Med Clin North Am"},{"issue":"10","key":"2026060904160451200_luag158-B2","doi-asserted-by":"crossref","DOI":"10.1111\/1753-0407.70012","article-title":"National burden and risk factors of diabetes mellitus in China from 1990 to 2021: results from the global burden of disease study 2021","volume":"16","author":"Deng","year":"2024","journal-title":"J Diabetes"},{"issue":"1","key":"2026060904160451200_luag158-B3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12933-024-02145-x","article-title":"Double diabetes-when type 1 diabetes meets type 2 diabetes: definition, pathogenesis and recognition","volume":"23","author":"Bielka","year":"2024","journal-title":"Cardiovasc Diabetol"},{"issue":"Supplement_1","key":"2026060904160451200_luag158-B4","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.2337\/dc26-S002","article-title":"2. diagnosis and classification of diabetes: standards of care in diabetes-2026","volume":"49","author":"American Diabetes Association Professional Practice Committee for Diabetes*","year":"2026","journal-title":"Diabetes Care"},{"issue":"11","key":"2026060904160451200_luag158-B5","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1007\/s00125-005-1960-7","article-title":"Latent autoimmune diabetes in adults (LADA) should be less latent","volume":"48","author":"Fourlanos","year":"2005","journal-title":"Diabetologia"},{"issue":"11","key":"2026060904160451200_luag158-B6","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2337\/diacare.23.11.1707","article-title":"\u201cLady-like\u201d: is there a latent autoimmune diabetes in the young?","volume":"23","author":"Lohmann","year":"2000","journal-title":"Diabetes Care"},{"key":"2026060904160451200_luag158-B7","article-title":"GAD65 antibody epitopes and genetic background in latent autoimmune diabetes in youth (LADY)","volume":"13","author":"Peng","year":"2022","journal-title":"Front Immunol"},{"key":"2026060904160451200_luag158-B8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pcad.2024.03.004","article-title":"Maturity-onset diabetes of the young (MODY) - in search of ideal diagnostic criteria and precise treatment","volume":"85","author":"Ze\u010devi\u0107","year":"2024","journal-title":"Prog Cardiovasc Dis"},{"key":"2026060904160451200_luag158-B9","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2025.112289","article-title":"Profile of monogenic diabetes: a pan-India study","volume":"226","author":"Mohan","year":"2025","journal-title":"Diabetes Res Clin Pract"},{"issue":"4","key":"2026060904160451200_luag158-B10","doi-asserted-by":"crossref","first-page":"e1455","DOI":"10.1210\/clinem\/dgab864","article-title":"Two new mutations in the CEL gene causing diabetes and hereditary pancreatitis: how to correctly identify MODY8 cases","volume":"107","author":"El Jellas","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2026060904160451200_luag158-B11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/jdi.14267","article-title":"Practice guideline: statement regarding treatment for suspected slowly progressive type 1 diabetes (SPIDDM; probable) cases (English version)","volume":"16","author":"Shimada","year":"2025","journal-title":"J Diabetes Investig"},{"issue":"1","key":"2026060904160451200_luag158-B12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12020-023-03512-6","article-title":"Clinical and genetic characteristics of CEL-MODY (MODY8): a literature review and screening in Chinese individuals diagnosed with early-onset type 2 diabetes","volume":"83","author":"Sun","year":"2024","journal-title":"Endocrine"},{"issue":"Supplement_1","key":"2026060904160451200_luag158-B13","doi-asserted-by":"crossref","first-page":"A391","DOI":"10.1210\/jendso\/bvab048.797","article-title":"Maturity onset diabetes of the young masquerading as new onset diabetes mellitus type 1","volume":"5","author":"Miller","year":"2021","journal-title":"J Endocr Soc"},{"issue":"6","key":"2026060904160451200_luag158-B14","doi-asserted-by":"crossref","DOI":"10.1002\/ccr3.4151","article-title":"GAD-65 antibodies in a case of HNF1A-maturity- onset diabetes of the young: double diabetes?","volume":"9","author":"Sjoholm","year":"2021","journal-title":"Clin Case Rep"},{"key":"2026060904160451200_luag158-B15","article-title":"The coexistence of autoimmune diabetes and maturity-onset diabetes of the young (MODY): a case series","volume":"2022","author":"O'Donovan","year":"2022","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"issue":"7","key":"2026060904160451200_luag158-B16","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.4239\/wjd.v14.i7.1137","article-title":"Maturity-onset diabetes of the young type 9 or latent autoimmune diabetes in adults: a case report and review of literature","volume":"14","author":"Zhou","year":"2023","journal-title":"World J Diabetes"},{"issue":"5","key":"2026060904160451200_luag158-B17","doi-asserted-by":"crossref","first-page":"552","DOI":"10.7861\/clinmedicine.8-5-552","article-title":"Latent autoimmune diabetes in the young","volume":"8","author":"Zachariah","year":"2008","journal-title":"Clin Med"},{"issue":"3","key":"2026060904160451200_luag158-B18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1297\/cpe.2024-0083","article-title":"A case of latent autoimmune diabetes in the young positive for zinc transporter 8 antibody with type 2 diabetes characteristics","volume":"34","author":"Matsuda","year":"2025","journal-title":"Clin Pediatr Endocrinol"},{"issue":"5","key":"2026060904160451200_luag158-B19","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/pedi.13348","article-title":"Latent autoimmune diabetes in youth shows greater autoimmunity than latent autoimmune diabetes in adults: evidence from a nationwide, multicenter, cross sectional study","volume":"23","author":"Cheng","year":"2022","journal-title":"Pediatr Diabetes"},{"key":"2026060904160451200_luag158-B20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1691377","article-title":"Latent autoimmune diabetes in youth","volume":"16","author":"Sun","year":"2025","journal-title":"Front Immunol"},{"issue":"5","key":"2026060904160451200_luag158-B21","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s13300-017-0299-7","article-title":"Possible long-term efficacy of sitagliptin, a dipeptidyl Peptidase-4 inhibitor, for slowly progressive type 1 diabetes (SPIDDM) in the stage of non-insulin-dependency: an open-label randomized controlled pilot trial (SPAN-S)","volume":"8","author":"Awata","year":"2017","journal-title":"Diabetes Ther"},{"issue":"1","key":"2026060904160451200_luag158-B22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/pedi.12973","article-title":"Demographic and clinical profile of youth onset diabetes patients in India-results from the baseline data of a clinic based registry of people with diabetes in India with young age at onset-[YDR-02]","volume":"22","author":"Praveen","year":"2021","journal-title":"Pediatr Diabetes"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/4\/7\/luag158\/68492716\/luag158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/4\/7\/luag158\/68492716\/luag158.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:16:13Z","timestamp":1780992973000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luag158\/8704251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,5,20]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luag158","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,5,20]]},"article-number":"luag158"}}