{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:47:49Z","timestamp":1791870469535,"version":"4.3.4"},"reference-count":10,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neuroendocrine tumors (NETs) are often associated with paraneoplastic features including carcinoid syndrome in up to 30% to 40% of cases. However, paraneoplastic thrombocytosis is a rare NET-associated condition. We report the case of a 59-year-old woman referred for significant and unexplained weight loss. Biological evaluation revealed thrombocytosis (900 \u00d7 109\/L). A thoracoabdominal and pelvic computed tomography (CT) scan revealed multiple liver and bone lesions, suggestive of metastatic disease. Colonoscopic evaluation identified a well-differentiated NET as the primary tumor. Hematologic explorations revealed no underlying hematological condition explaining thrombocytosis. Cold somatostatin analogue treatment was started and resulted in initial stabilization of the disease. However, follow-up CT scan showed liver progression after 2 years concomitant with worsening thrombocytosis. 68Ga-DOTATOC positron emission tomography showed intense uptake of all known tumoral lesions; the patient was then treated with 177Lu-DOTATATE. Under 177Lu-DOTATATE treatment, platelet counts gradually decreased until normalization 8 weeks after the first injection, remaining within the normal range for up to 18 months, in parallel with clinical improvement. In conclusion, we report a rare case of paraneoplastic thrombocytosis associated with a small bowel NET showing rapid biological resolution from the first cycle of 177Lu-DOTATATE.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag166","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:50:07Z","timestamp":1783165807000},"source":"Crossref","is-referenced-by-count":0,"title":["Unusual paraneoplastic thrombocytosis in small bowel neuroendocrine tumor responding to 177Lu-DOTATATE"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3564-786X","authenticated-orcid":false,"given":"Eve","family":"Piekarski","sequence":"first","affiliation":[{"name":"Nuclear Medicine Department, Cochin University Hospital , Paris 75014 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-S\u00e9gol\u00e8ne","family":"Cottereau","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Cochin University Hospital , Paris 75014 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4420-8340","authenticated-orcid":false,"given":"Romain","family":"Coriat","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Cochin University Hospital , Paris 75014 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Willems","sequence":"additional","affiliation":[{"name":"Hematology Department, Cochin University Hospital , Paris 75014 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Bouys","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Cochin University Hospital , Paris 75014 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Tenenbaum","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Cochin University Hospital , Paris 75014 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"suppl 1","key":"2026101301313442000_luag166-B1","doi-asserted-by":"crossref","first-page":"e490s","DOI":"10.6061\/clinics\/2018\/e490s","article-title":"Carcinoid syndrome: update on the pathophysiology and treatment","volume":"73","author":"Rubin de Celis Ferrari","year":"2018","journal-title":"Clinics (Sao Paulo)"},{"key":"2026101301313442000_luag166-B2","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3332\/ecancer.2016.662","article-title":"Complications from carcinoid syndrome: review of the current evidence","volume":"10","author":"Mota","year":"2016","journal-title":"Ecancermedicalscience"},{"issue":"1","key":"2026101301313442000_luag166-B3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1470-2045(07)70410-2","article-title":"Gastroenteropancreatic neuroendocrine tumours","volume":"9","author":"Modlin","year":"2008","journal-title":"Lancet Oncol"},{"issue":"4","key":"2026101301313442000_luag166-B4","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/cncr.11105","article-title":"A 5-decade analysis of 13,715 carcinoid tumors","volume":"97","author":"Modlin","year":"2003","journal-title":"Cancer"},{"key":"2026101301313442000_luag166-B5","first-page":"103664","article-title":"Primary neuroendocrine carcinoma of the breast with paraneoplastic thrombocytosis; a rare case report","volume":"77","author":"Kherbek","year":"2022","journal-title":"Ann Med Surg (Lond)"},{"issue":"1","key":"2026101301313442000_luag166-B6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/cancers13010067","article-title":"Histopathological chromogranin A-positivity is associated with right-sided colorectal cancers and worse prognosis","volume":"13","author":"Herold","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"3","key":"2026101301313442000_luag166-B7","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3390\/ijms21030788","article-title":"The \u201cJanus face\u201d of platelets in cancer","volume":"21","author":"Catani","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"7","key":"2026101301313442000_luag166-B8","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMoa1110352","article-title":"Paraneoplastic thrombocytosis in ovarian cancer","volume":"366","author":"Stone","year":"2012","journal-title":"N Engl J Med"},{"issue":"2","key":"2026101301313442000_luag166-B9","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1182\/blood-2014-03-562538","article-title":"Paraneoplastic thrombocytosis: the secrets of tumor self-promotion","volume":"124","author":"Lin","year":"2014","journal-title":"Blood"},{"issue":"20","key":"2026101301313442000_luag166-B10","doi-asserted-by":"crossref","first-page":"6191","DOI":"10.3390\/jcm11206191","article-title":"Inflammatory cytokines associated with diagnosis, tumor grade and prognosis in patients with neuroendocrine tumors","volume":"11","author":"Geisler","year":"2022","journal-title":"J Clin Med"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/4\/11\/luag166\/71891630\/luag166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/4\/11\/luag166\/71891630\/luag166.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:31:39Z","timestamp":1791869499000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luag166\/8911671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,9,25]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luag166","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,11]]},"published":{"date-parts":[[2026,9,25]]},"article-number":"luag166"}}