{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T10:48:25Z","timestamp":1782989305234,"version":"3.54.5"},"reference-count":17,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Parathyroid carcinoma is a rare form of cancer. We describe a 45-year-old man diagnosed with parathyroid carcinoma long after initial surgery. At age 24, the patient had elevated serum calcium and intact parathyroid hormone (PTH). Ultrasonography revealed a left lower parathyroid tumor, which led to the diagnosis of primary hyperparathyroidism. Parathyroidectomy was performed, and the pathological diagnosis was parathyroid adenoma. At age 32, hypercalcemia and elevated intact PTH recurred, and computed tomography revealed a right lung tumor with focal uptake on 99mTc-methoxyisobutylisonitrile scintigraphy, which was clinically diagnosed as probable pulmonary metastasis from a parathyroid neoplasm; however, the patient declined further evaluation. At age 45, progressive hyperparathyroidism and enlargement of the right lung tumor were identified, leading to thoracoscopic resection. The resected tumor showed histopathological features similar to those of the previously resected parathyroid tumor. Immunohistochemistry revealed a low Ki-67 index but complete loss of nuclear parafibromin expression, confirming metastatic parathyroid carcinoma. Seven years after surgery, there was no evidence of recurrence or metastasis. Because it is often difficult to differentiate parathyroid carcinoma from parathyroid adenoma, and recurrence or metastasis may occur after a long interval, the possibility of carcinoma should always be considered and long-term follow-up is essential.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag171","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T11:22:26Z","timestamp":1782127346000},"source":"Crossref","is-referenced-by-count":0,"title":["Parathyroid carcinoma diagnosed after pulmonary metastases 8 years after initial parathyroidectomy"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7531-5028","authenticated-orcid":false,"given":"Naoki","family":"Matsuda","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University , Yufu City, Oita 879-5593 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kansuke","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Oita Red Cross Hospital , Oita City, Oita 870-0033 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mizuuchi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shimonoseki City Hospital , Shimonoseki City, Yamaguchi 750-8520 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Imagawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Oita San-ai Medical Center , Oita City, Oita 870-1151 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Kameyama","sequence":"additional","affiliation":[{"name":"Department of Pathology, Showa Medical University Northern Yokohama Hospital , Yokohama City, Kanagawa 224-8503 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6506-4820","authenticated-orcid":false,"given":"Hirotaka","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University , Yufu City, Oita 879-5593 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"issue":"4","key":"2026070205434433000_luag171-B1","doi-asserted-by":"crossref","first-page":"e220287","DOI":"10.1530\/ERC-22-0287","article-title":"Diagnosis and management of parathyroid carcinoma: a state-of-the-art review","volume":"30","author":"Roser","year":"2023","journal-title":"Endocr Relat Cancer"},{"issue":"2","key":"2026070205434433000_luag171-B2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1210\/jcem.86.2.7207","article-title":"Clinical review 122: parathyroid carcinoma","volume":"86","author":"Shane","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2026070205434433000_luag171-B3","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/BF01665308","article-title":"Diagnosis and treatment of patients with parathyroid carcinoma: an update and review","volume":"15","author":"Obara","year":"1991","journal-title":"World J Surg"},{"issue":"3","key":"2026070205434433000_luag171-B4","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/(SICI)1097-0142(19990801)86:3<538::AID-CNCR25>3.0.CO;2-K","article-title":"Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995: a National Cancer Data Base Report. The American College of Surgeons Commission on Cancer and the American Cancer Society","volume":"86","author":"Hundahl","year":"1999","journal-title":"Cancer"},{"issue":"8","key":"2026070205434433000_luag171-B5","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/hed.20049","article-title":"Parathyroid carcinoma: a 22-year experience","volume":"26","author":"Busaidy","year":"2004","journal-title":"Head Neck"},{"issue":"12","key":"2026070205434433000_luag171-B6","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1359\/jbmr.081018","article-title":"Parathyroid carcinoma","volume":"23","author":"Marcocci","year":"2008","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2026070205434433000_luag171-B7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1507\/endocrj.48.213","article-title":"Ultrasonographic features of parathyroid carcinoma","volume":"48","author":"Hara","year":"2001","journal-title":"Endocr 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