{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:00:45Z","timestamp":1784718045312,"version":"3.55.0"},"reference-count":21,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adipsic arginine vasopressin deficiency (AAVP-D) is a rare hypothalamic disorder, with inadequate vasopressin production and impaired thirst, resulting in sodium and water dysregulation. It poses multiple challenges, including increased morbidity and mortality. We present a 24-year-old female who developed confusion after neurosurgical debulking of a central neurocytoma. Investigations revealed hypernatremia alongside raised plasma osmolality, low urine osmolality, polyuria, and adipsia. Transient AAVP-D was suspected; it was successfully treated with intravenous desmopressin, which resolved predischarge. One week later, she re-presented to the hospital with confusion. Recurrence of hypernatremia, plasma hyperosmolality, and polyuria occurred and permanent AAVP-D was suspected. She was commenced on oral desmopressin 50 mcg\/day, titrated to 150\u2005mcg\/day, with strict oral fluid regime of 2 L\/day. She remains adipsic 24 months postoperatively. Her case highlights the multiple challenges of AAVP-D. Management includes calculating a daily fluid intake goal and titration with desmopressin to ensure consistent urine output, patient weight, and plasma sodium levels with careful outpatient monitoring.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag175","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:01:13Z","timestamp":1784714473000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical and diagnostic complexities of adipsic arginine vasopressin deficiency"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8235-5494","authenticated-orcid":false,"given":"Nadia","family":"Chaudhury","sequence":"first","affiliation":[{"name":"University Hospitals Coventry and Warwickshire Department of Diabetes and Endocrinology, , Coventry CV2 2DX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdur-Raoof","family":"Sheikh","sequence":"additional","affiliation":[{"name":"University Hospitals Coventry and Warwickshire Department of Diabetes and Endocrinology, , Coventry CV2 2DX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranganatha","family":"Rao","sequence":"additional","affiliation":[{"name":"University Hospitals Coventry and Warwickshire Department of Diabetes and Endocrinology, , Coventry CV2 2DX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"issue":"6665","key":"2026072206010589100_luag175-B1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1136\/bmj.298.6665.2","article-title":"Postoperative diabetes insipidus","volume":"298","author":"Seckl","year":"1989","journal-title":"BMJ"},{"issue":"7","key":"2026072206010589100_luag175-B2","article-title":"When thirst ceases to exist: a case report and literature review of adipsic diabetes insipidus following coil embolization of a ruptured anterior communicating artery 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