{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:26:46Z","timestamp":1783906006462,"version":"3.55.0"},"reference-count":13,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Carcinoid heart disease (CaHD) is a well-recognized complication of functional neuroendocrine tumors (NETs), typically occurring in the presence of hepatic metastases that permit vasoactive substances to reach the systemic circulation. Its occurrence in the absence of liver involvement is uncommon and may delay diagnosis. We report a 46-year-old woman who was incidentally found to have severe tricuspid regurgitation during preoperative evaluation for uterine fibroids. Further evaluation revealed elevated 24-hour urinary 5-hydroxyindoleacetic acid and markedly increased chromogranin A levels, raising suspicion of a functional NET. Imaging identified a large somatostatin receptor\u2013avid pelvic mass without evidence of hepatic or distant metastasis. The patient underwent successful surgical excision following perioperative octreotide infusion, and histopathology confirmed a Grade 1 well-differentiated neuroendocrine tumor arising from the mesosalpinx\/peritoneal region suggestive of a primary extraintestinal neuroendocrine tumor. Postoperatively, she demonstrated biochemical improvement and clinical stabilization on somatostatin analog therapy; however, severe tricuspid regurgitation persisted. This case highlights an unusual presentation of CaHD in the absence of hepatic metastasis and underscores the importance of considering neuroendocrine tumors in patients with unexplained right-sided valvular heart disease.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag182","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:03:10Z","timestamp":1783904590000},"source":"Crossref","is-referenced-by-count":0,"title":["A silent tumor, a loud valve: carcinoid heart disease as the first manifestation of a pelvic neuroendocrine tumor"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5415-1611","authenticated-orcid":false,"given":"Pinaki","family":"Dutta","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Postgraduate Institute of Medical Education and Research (PGIMER) , Chandigarh 160012 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research (PGIMER) , Chandigarh 160012 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay Kumar","family":"Bhadada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Postgraduate Institute of Medical Education and Research (PGIMER) , Chandigarh 160012 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7247-5492","authenticated-orcid":false,"given":"Vivek","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Postgraduate Institute of Medical Education and Research (PGIMER) , Chandigarh 160012 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghuraman","family":"Soundararajan","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research (PGIMER) , Chandigarh 160012 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research (PGIMER) , Chandigarh 160012 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"issue":"2","key":"2026071221005364500_luag182-B1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000225952","article-title":"Mallorca consensus conference participants; European Neuroendocrine Tumor Society. ENETS consensus guidelines for the standards of care in neuroendocrine tumors: follow-up and documentation","volume":"90","author":"Arnold","year":"2009","journal-title":"Neuroendocrinology"},{"issue":"3","key":"2026071221005364500_luag182-B2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.amjcard.2007.08.045","article-title":"Analysis of 150 patients with carcinoid syndrome seen in a single year at one institution in the first decade of the twenty-first century","volume":"101","author":"Bhattacharyya","year":"2008","journal-title":"Am J Cardiol"},{"issue":"4","key":"2026071221005364500_luag182-B3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000381930","article-title":"Carcinoid heart disease: from pathophysiology to treatment\u2013\u2018Something in the way it moves\u2019","volume":"101","author":"Grozinsky-Glasberg","year":"2015","journal-title":"Neuroendocrinology"},{"issue":"11","key":"2026071221005364500_luag182-B4","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa021451","article-title":"Factors associated with progression of carcinoid heart disease","volume":"348","author":"M\u00f8ller","year":"2003","journal-title":"N Engl J Med"},{"issue":"6","key":"2026071221005364500_luag182-B5","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1053\/j.gastro.2005.03.038","article-title":"Current status of gastrointestinal carcinoids","volume":"128","author":"Modlin","year":"2005","journal-title":"Gastroenterology"},{"issue":"2","key":"2026071221005364500_luag182-B6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.amjcard.2006.07.092","article-title":"Carcinoid heart disease in patients without hepatic metastases","volume":"99","author":"Bernheim","year":"2007","journal-title":"Am J Cardiol"},{"issue":"9","key":"2026071221005364500_luag182-B7","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.radcr.2020.07.014","article-title":"Primary retroperitoneal neuroendocrine tumor with nonspecific presentation: a case report","volume":"15","author":"Taei","year":"2020","journal-title":"Radiol Case Rep"},{"issue":"1","key":"2026071221005364500_luag182-B8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13244-023-01417-6","article-title":"Primary and secondary tumors of the peritoneum: key imaging features and differential diagnosis with surgical and pathological correlation","volume":"14","author":"Miguez Gonz\u00e1lez","year":"2023","journal-title":"Insights Imaging"},{"issue":"11","key":"2026071221005364500_luag182-B9","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1056\/NEJM199903183401107","article-title":"Carcinoid tumors","volume":"340","author":"Kulke","year":"1999","journal-title":"N Engl J Med"},{"issue":"2","key":"2026071221005364500_luag182-B10","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/1097-0142(197508)36:2<404::AID-CNCR2820360216>3.0.CO;2-0","article-title":"Insular carcinoid primary in the ovary. 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