{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:26:47Z","timestamp":1783906007740,"version":"3.55.0"},"reference-count":13,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 46-year-old man with a 15-year history of type 2 diabetes had maintained hemoglobin A1c (HbA1c) around 6.5% (SI: 48\u2005mmol\/mol) (reference range, 4.7%-6.2% [28-44\u2005mmol\/mol]) for approximately 12 years on saxagliptin monotherapy, but glycemic control worsened over 1 year despite additional ipragliflozin and metformin. Abdominal computed tomography (CT), performed after health-screening urine dipstick protein positivity, detected a left adrenal mass. He had tachycardia and weight loss but no palpitations, headache, pallor, or diaphoresis. Biochemical tests showed marked catecholamine excess and elevated 24-hour urinary metanephrines, and iodine-123 metaiodobenzylguanidine (123I-MIBG) scintigraphy showed concordant uptake. Before surgery, fasting C-peptide was 0.64\u2005ng\/mL (SI: 0.21\u2005nmol\/L) (reference range, 0.80-2.50\u2005ng\/mL [SI: 0.26-0.83\u2005nmol\/L]), C-peptide index was 0.51, and homeostasis model assessment of beta-cell function (HOMA-beta) was 11.0. After alpha blockade and volume expansion, laparoscopic left adrenalectomy confirmed pheochromocytoma. Antihypertensive and glucose-lowering medications were discontinued postoperatively, and glycemic control remained stable without antidiabetic medication at 6 months. This case highlights pheochromocytoma as a reversible endocrine cause of rapid worsening of previously stable type 2 diabetes.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag185","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:03:12Z","timestamp":1783904592000},"source":"Crossref","is-referenced-by-count":0,"title":["Pheochromocytoma unmasked by rapid deterioration of previously stable type 2 diabetes"],"prefix":"10.1210","volume":"4","author":[{"given":"Nozomi","family":"Sasatsuki","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology, Juntendo University Urayasu Hospital , Urayasu-city, Chiba 279-0021 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Juntendo University Urayasu Hospital , Urayasu-city, Chiba 279-0021 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