{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T02:25:29Z","timestamp":1787538329191,"version":"build-2736575974"},"reference-count":16,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Osteosclerosis refers to an abnormal increase in bone density resulting from excessive bone formation and\/or reduced bone resorption. We present a case of a 31-year-old woman with acute-on-chronic abdominal pain, flushing, and diarrhea. Diffuse, mottled sclerosis involving the entire axial and appendicular skeleton was incidentally identified on imaging. Diagnostic investigations for osteosclerosis revealed a raised tryptase, leading to a bone marrow and trephine analysis. This demonstrated abnormally spindle-shaped mast cells, more than 15 in a group, with positive staining for tryptase which was consistent with systemic mastocytosis (SM). In the absence of \u201cC\u201d findings, a diagnosis of indolent SM complicated by diffuse osteosclerosis was made. Treatment with a histamine type-2 receptor antagonist provided mild symptomatic relief. In this report, we discuss the differential causes of osteosclerosis and the pathogenesis of bone manifestations related to SM, along with subtype-specific SM treatment options.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag228","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:40:09Z","timestamp":1785843609000},"source":"Crossref","is-referenced-by-count":0,"title":["Diffuse osteosclerosis in a patient with systemic mastocytosis"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8922-6601","authenticated-orcid":false,"given":"Huy H","family":"Do","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes, Western Health , St. Albans, Victoria 3021 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balasubramanian","family":"Krishnamurthy","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Western Health , St. Albans, Victoria 3021 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Grill","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Western Health , St. Albans, Victoria 3021 ,","place":["Australia"]},{"name":"Department of Medicine, The University of Melbourne , Parkville, Victoria 3010 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Leow","sequence":"additional","affiliation":[{"name":"Department of Haematology, Western Health , St. Albans, Victoria 3021 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8846-6168","authenticated-orcid":false,"given":"Hanh H","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Western Health , St. Albans, Victoria 3021 ,","place":["Australia"]},{"name":"Department of Medicine, The University of Melbourne , Parkville, Victoria 3010 ,","place":["Australia"]},{"name":"Department of Medicine, School of Clinical Sciences, Monash University , Clayton, Victoria 3168 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"2026082322025919000_luag228-B1","first-page":"121","volume-title":"Biopsy of Bone in Internal Medicine: An Atlas and Sourcebook","author":"Bartl","year":"1993"},{"issue":"5","key":"2026082322025919000_luag228-B2","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.jaip.2023.02.007","article-title":"Bone and cytokine markers associated with bone disease in systemic mastocytosis","volume":"11","author":"Rama","year":"2023","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"2","key":"2026082322025919000_luag228-B3","article-title":"Skin and bones: systemic mastocytosis and 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