{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:08:13Z","timestamp":1789546093256,"version":"build-2803163510"},"reference-count":20,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 53-year-old man underwent resection of a nonfunctional 9\u2005cm oncocytic adrenal cortical carcinoma (ACC) with focal high-grade features. Two years later he presented again, with gynecomastia and elevated levels of estradiol, 11-deoxycortisol, and serum calcium (10.5\u2005mg\/dL, SI: 2.62\u2005mmol\/L) (reference range 8.4-10.2\u2005mg\/dL [SI: 2.10-2.55\u2005mmol\/L]). Imaging demonstrated locally recurrent ACC, which was resected. Steroid excess resolved and he started mitotane. Months after, his calcium was 11.9\u2005mg\/dL (SI: 2.97\u2005mmol\/L), parathyroid hormone (PTH) 209\u2005pg\/mL (SI: 22.0\u2005pmol\/L) (reference range 15-65\u2005pg\/mL [SI: 1.6-6.9\u2005pmol\/L]), and parathyroid hormone\u2013related peptide (PTHrp) was undetectable. Germline genetic testing (TP53, MSH2, MSH6, MLH1, PMS2, and MEN1) was negative; localizing imaging demonstrated possible right inferior parathyroid adenoma. He underwent 4-gland parathyroid exploration. Right inferior parathyroid (460\u2005mg) was excised, superior parathyroids appeared normal, and left inferior parathyroid was not identified. Intraoperative parathyroid hormone (IOPTH) did not drop appropriately. Follow-up calcium rose to 13.1\u2005mg\/dL (SI: 3.27\u2005mmol\/L) and PTH to 336\u2005pg\/mL (SI: 35.6\u2005pmol\/L). Repeat imaging demonstrated ACC recurrence. After cytoreductive surgery (nephrectomy and omentectomy) and heated intraperitoneal chemotherapy (HIPEC), calcium and PTH normalized. Staining of the recurrent ACC demonstrated PTH positivity. This is a novel case of PTH-secreting ACC and concomitant parathyroid adenoma.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag253","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:51:06Z","timestamp":1787140266000},"source":"Crossref","is-referenced-by-count":0,"title":["Concomitant parathyroid hormone-secreting oncocytic adrenocortical carcinoma and parathyroid adenoma"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5956-8288","authenticated-orcid":false,"given":"Natalie A","family":"Moreno","sequence":"first","affiliation":[{"name":"Division of Endocrine Surgery, Department of Surgery, Johns Hopkins University School of Medicine , Baltimore, MD 21287 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8832-9385","authenticated-orcid":false,"given":"Amir H","family":"Hamrahian","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD 21287 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3329-7106","authenticated-orcid":false,"given":"Christian F","family":"Meyer","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD 21287 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9404-6254","authenticated-orcid":false,"given":"Ciera","family":"Mangone","sequence":"additional","affiliation":[{"name":"Division of Surgical Pathology, Department of Pathology, Johns Hopkins University School of Medicine , Baltimore, MD 21287 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezra","family":"Baraban","sequence":"additional","affiliation":[{"name":"Division of Surgical Pathology, Department 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