{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:08:09Z","timestamp":1789546089393,"version":"build-2803163510"},"reference-count":20,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gonadotropin-resistant ovary syndrome (GROS) is an endocrine disorder often associated with infertility due to a poor ovarian response to exogenous gonadotropins during controlled ovarian stimulation. The etiology of GROS is not completely elucidated. Pharmacogenetic studies suggest that polymorphisms in the genes encoding the follicle-stimulating hormone receptor (FSHR) and the FSH beta-subunit (FSHB) may contribute to the pathogenesis of GROS in some patients. We report a case of a 26-year-old woman with polymorphisms in the FSHR and FSHB genes who fulfilled the clinical and paraclinical criteria for GROS except for having a normal female karyotype. Karyotype analyses revealed low-frequency mosaicism for Turner syndrome, which, like GROS, may predispose to premature ovarian insufficiency (POI). This finding warrants regular follow-up, early detection of POI, and timely initiation of hormone replacement therapy. This case describes a woman with both GROS and mosaicism for monosomy X and triple X, a combination not previously described in the available literature. The combination supports an oocyte-related cause of infertility and suggests oocyte donation as the most effective treatment option for patients with a similar genetic profile. The patient achieved a live birth following in vitro fertilization with a donated oocyte.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag255","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:12:28Z","timestamp":1788520348000},"source":"Crossref","is-referenced-by-count":0,"title":["Gonadotropin-resistant ovary syndrome in a hypergonadotropic patient with\n                    <i>FSHR\/FSHB<\/i>\n                    polymorphisms and abnormal karyotype"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4582-8313","authenticated-orcid":false,"given":"Aleksandra","family":"Ivanoska Trajcevski","sequence":"first","affiliation":[{"name":"The Fertility Clinic, Copenhagen University Hospital Hvidovre , Hvidovre 2650 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5678-2925","authenticated-orcid":false,"given":"Anne Benedicte","family":"Juul","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Copenhagen University Hospital Hvidovre , Hvidovre 2650 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Langhoff Thuesen","sequence":"additional","affiliation":[{"name":"The Fertility Clinic, Copenhagen University Hospital Hvidovre , Hvidovre 2650 ,","place":["Denmark"]},{"name":"Institute of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences , Copenhagen 2200 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"issue":"4","key":"2026091603524760200_luag255-B1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0015-0282(16)36362-2","article-title":"Premature ovarian failure","volume":"18","author":"de Moraes-Ruehsen","year":"1967","journal-title":"Fertil 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