{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:01:41Z","timestamp":1790337701925,"version":"4.1.0"},"reference-count":14,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"AIRC","doi-asserted-by":"publisher","award":["IG2019-23069"],"award-info":[{"award-number":["IG2019-23069"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tumor-to-tumor metastasis (TTM) is an established but rare entity. Lung carcinoma metastasizes commonly to adrenal glands; however, metastases into an already existing adrenal gland tumor are a rare finding. A 78-year-old man was diagnosed with pheochromocytoma, and during the disease staging, lung involvement was revealed. Functional imaging with both 18F-fluorodeoxyglucose (18F-FDG) and 68Ga-DOTA-Tyr3-Octreotate (68Ga-DOTA-TATE) positron emission tomography (PET) was performed: 18FDG-PET showed mild uptake in both the adrenal and pulmonary lesions, whereas 68Ga-DOTA-TATE-PET revealed intense uptake confined to the adrenal mass. This discordant pattern suggested the presence of 2 biologically distinct lesions. The right adrenal gland was surgically removed, and histology and immunohistochemistry confirmed 2 components within the tumor: a pheochromocytoma that included a lung cancer metastasis. Histopathological confirmation of the pulmonary primary lesion was not available. This is the second published case of a TTM of lung carcinoma inside a pheochromocytoma. Tumor-to-tumor metastasis should be considered in pathological diagnosis.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag283","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:22:02Z","timestamp":1788520922000},"source":"Crossref","is-referenced-by-count":0,"title":["Metastasis of lung carcinoma in a pheochromocytoma"],"prefix":"10.1210","volume":"4","author":[{"given":"Antonio","family":"Gigante","sequence":"first","affiliation":[{"name":"Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin , Orbassano 10043 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9981-3314","authenticated-orcid":false,"given":"Erika","family":"Messina","sequence":"additional","affiliation":[{"name":"Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin , Orbassano 10043 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Massa","sequence":"additional","affiliation":[{"name":"Pathology Unit and Department of Oncology, San Luigi Gonzaga Hospital , University of Turin, Orbassano 10043 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0719-105X","authenticated-orcid":false,"given":"Marco","family":"Volante","sequence":"additional","affiliation":[{"name":"Pathology Unit and Department of Oncology, San Luigi Gonzaga Hospital , University of Turin, Orbassano 10043 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, A.O. Santa Croce e Carle , Cuneo 12100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Terzolo","sequence":"additional","affiliation":[{"name":"Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin , Orbassano 10043 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"issue":"2","key":"2026092507131213400_luag283-B1","first-page":"151","article-title":"Tumor-to-tumor metastasis of the central nervous system","volume":"24","author":"Erdogan","year":"2014","journal-title":"Turk Neurosurg"},{"issue":"4","key":"2026092507131213400_luag283-B2","first-page":"367","article-title":"Tumor-to-tumor metastasis: pathology and neuroimaging considerations","volume":"5","author":"Moody","year":"2012","journal-title":"Int J Clin Exp Pathol"},{"issue":"2","key":"2026092507131213400_luag283-B3","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jocn.2014.07.002","article-title":"Tumor-to-tumor metastasis: breast carcinoma to meningioma","volume":"22","author":"Sayegh","year":"2015","journal-title":"J Clin Neurosci"},{"issue":"1","key":"2026092507131213400_luag283-B4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13000-019-0816-2","article-title":"Tumor-to-tumor metastasis: a rare case of breast carcinoma metastasizing to a pheochromocytoma, and a literature review","volume":"14","author":"Tan","year":"2019","journal-title":"Diagn Pathol"},{"issue":"2","key":"2026092507131213400_luag283-B5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0344-0338(87)80109-7","article-title":"Neoplasm to neoplasm metastasis. 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