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Several studies in animal models have shown that androgens have neuroprotective effects in the brain and stimulate axonal regeneration. The presence of neuronal androgen receptors in the peripheral and central nervous system suggests that androgen therapy might be useful in the treatment of neurodegenerative diseases. To illustrate, androgen therapy reduced inflammation, amyloid-\u03b2 deposition, and cognitive impairment in patients with AD. As well, improvements in remyelination in MS have been reported; by comparison, only variable results are observed in androgen treatment of PD. In ALS, androgen administration stimulated motoneuron recovery from progressive damage and regenerated both axons and dendrites. Only a few clinical studies are available in human individuals despite the safety and low cost of androgen therapy. Clinical evaluations of the effects of androgen therapy on these devastating diseases using large populations of patients are strongly needed.<\/jats:p>","DOI":"10.1210\/jendso\/bvaa120","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T14:17:02Z","timestamp":1598019422000},"source":"Crossref","is-referenced-by-count":63,"title":["Androgen Therapy in Neurodegenerative Diseases"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3689-9970","authenticated-orcid":false,"given":"Vittorio Emanuele","family":"Bianchi","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Clinical Center Stella Maris, Strada Rovereta, Falciano, San Marino"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rizzi","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milano-Bicocca, Monza, 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