{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T02:58:19Z","timestamp":1787194699887,"version":"build-2736575974"},"reference-count":46,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS050597"],"award-info":[{"award-number":["R01NS050597"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K23HD092588"],"award-info":[{"award-number":["K23HD092588"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Klinefelter syndrome (KS) is the most common sex aneuploidy in men. Affected males have hypogonadism, and, as a result, face an increased risk for osteoporosis and fractures. Androgen therapy is standard in adolescents and adults with KS but has not been used earlier in childhood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine the effects of androgen treatment on bone mass in children with KS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Randomized, double-blind, placebo-controlled clinical trial of oxandrolone (OX; 0.06 mg\/kg daily; n\u2005=\u200538) versus placebo (PL; n\u2005=\u200540) for 2 years in boys with KS (ages 4-12 years). Changes in bone mass were examined by digital x-ray radiogrammetry, which determines the Bone Health Index (BHI) and standard deviation score (SDS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>BHI SDS was similar between groups at baseline (\u20130.46\u2005\u00b1\u20051.1 vs \u20130.34\u2005\u00b1\u20051.0 OX vs PL, P\u2005&amp;gt;\u2005.05) and higher in the OX group at 2 years (\u20130.1\u2005\u00b1\u20051.3 vs \u20130.53\u2005\u00b1\u20050.9, OX vs PL, P\u2005&amp;lt;\u2005.01). At baseline, BHI SDS values of all subjects were not normally distributed with 25.7% of subjects plotted below \u20131 SDS (P\u2005&amp;lt;\u2005.001), suggesting a deficit in bone mass. In total, 13.5% of subjects had sustained a fracture and their BHI SDS was lower than those with no fractures (\u20131.6\u2005\u00b1\u20051.3 vs \u20130.3\u2005\u00b1\u20051.0, P\u2005=\u2005.004).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Bone mass using BHI SDS is reduced in some children with KS and improves with OX. Since these individuals are at risk for osteoporosis, age-appropriate androgen replacement and future studies on bone health in children with KS should be further explored.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvab016","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T17:18:21Z","timestamp":1612977501000},"source":"Crossref","is-referenced-by-count":14,"title":["Cortical Bone Mass is Low in Boys with Klinefelter Syndrome and Improves with Oxandrolone"],"prefix":"10.1210","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1941-8277","authenticated-orcid":false,"given":"Maria G","family":"Vogiatzi","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanlee M","family":"Davis","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine, Department of Pediatrics, Section of Endocrinology, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith L","family":"Ross","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University, Department of Pediatrics, Philadelphia, PA, United States"},{"name":"A.I. 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