{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:46:56Z","timestamp":1787021216490,"version":"build-2736575974"},"reference-count":35,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002489"],"award-info":[{"award-number":["UL1TR002489"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UNC Thurston Arthritis Research Center\u2019s Core Center for Clinical Research"},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30AR072580"],"award-info":[{"award-number":["P30AR072580"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>The contribution of lumbar scoliosis to osteoporosis is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aimed to determine the prevalence and relationship of lumbar scoliosis to osteoporosis in aging women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional analysis used dual-energy x-ray absorptiometry (DXA) scans of randomly selected groups of postmenopausal women (64-68, 74-78, and 84-88 years; N\u2005=\u2005300 each) in a university teaching hospital from 2014 to 2019. Lumbar Cobb angle was tested for an association to femoral neck (FN), total hip (TH), and spine T score, age, weight, and ethnicity. Logistic regression tested an association between scoliosis (Cobb angle\u2005&amp;gt;\u200510\u00b0) and osteoporosis (T score\u2005\u2264\u2005\u20132.5). Available sequential DXA scans (N\u2005=\u200551) were analyzed for changes in Cobb angle using a linear mixed model of these longitudinal data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Osteoporosis and Cobb angle both increased with age: from 22% and 4.4 (SD\u2005=\u20057.8) respectively in 64- to 68-year-olds to 32.9% and to 9.7 (SD\u2005=\u20059.2) in women age 84 to 88 years. The prevalence of clinically significant scoliosis rose from 11.5% in the youngest group, to 27.3% and 39.4% in the age 74 to 78 and 84 to 88 cohorts, respectively. Cobb angle increased 0.7\u00b0 per year of follow-up. After adjusting for covariates, there was no significant association between T scores at any site (TH, FN, or spine) and Cobb angle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Based on screening DXAs, the incidence and degree of lumbar scoliosis increases significantly in women between age 65 and 85 years. There was no association between the incidence of lumbar scoliosis and FN bone density.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jendso\/bvab018","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T20:45:09Z","timestamp":1613421909000},"source":"Crossref","is-referenced-by-count":5,"title":["Lumbar Scoliosis in Postmenopausal Women Increases with Age but is not Associated with Osteoporosis"],"prefix":"10.1210","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3534-8667","authenticated-orcid":false,"given":"Janet","family":"Rubin","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27514, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0022-1025","authenticated-orcid":false,"given":"Rebecca J","family":"Cleveland","sequence":"additional","affiliation":[{"name":"Thurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA"},{"name":"Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9176-3844","authenticated-orcid":false,"given":"Alexander","family":"Padovano","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27514, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hu","sequence":"additional","affiliation":[{"name":"Thurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA"},{"name":"Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9790-8645","authenticated-orcid":false,"given":"Maya","family":"Styner","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27514, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27514, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"issue":"9","key":"2021121114115944900_CIT0001","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1097\/01.brs.0000160842.43482.cd","article-title":"Adult scoliosis: prevalence, SF-36, and nutritional parameters in an elderly volunteer population","volume":"30","author":"Schwab","year":"2005","journal-title":"Spine (Phila Pa 1976)."},{"issue":"1","key":"2021121114115944900_CIT0002","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1359\/jbmr.0809010","article-title":"Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial","volume":"24","author":"Brown","year":"2009","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2021121114115944900_CIT0003","first-page":"265","article-title":"Dose-response relationships for alendronate treatment in osteoporotic elderly women. 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