{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:12:57Z","timestamp":1790633577678,"version":"4.1.0"},"reference-count":35,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Alemtuzumab (ALZ), a CD52 monoclonal antibody, is highly efficacious in multiple sclerosis; however, side effects are common. Autoimmune thyroid disease (Graves\u2019 disease and Hashimoto thyroiditis) is a well-known complication of ALZ. Treatment of ALZ-induced Graves\u2019 disease can be challenging, and even more difficult during pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case description<\/jats:title>\n                  <jats:p>We present a case of severe ALZ-induced Graves\u2019 disease with a rapid increase in thyrotropin receptor antibodies (TRAb 240 IU\/L) and thyrotoxicosis in early pregnancy. Treatment with high doses of antithyroid medication was needed. There was high risk of both fetal and neonatal thyrotoxicosis. Serial fetal sonography showed normal development. The newborn baby presented high levels of TRAb (240 IU\/L) and developed neonatal thyrotoxicosis on day 8. Adequate monitoring, treatment, and follow-up of the newborn baby ensured normal thyroid function until disappearance of TRAb 6 weeks after birth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Multiple sclerosis patients treated with ALZ may develop severe Graves\u2019 disease with an increased risk of both fetal and neonatal thyrotoxicosis. Close follow-up with a multidisciplinary approach is needed to ensure a healthy outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jendso\/bvab044","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T16:00:07Z","timestamp":1615996807000},"source":"Crossref","is-referenced-by-count":7,"title":["Management of Severe Graves\u2019 Hyperthyroidism in Pregnancy Following Immune Reconstitution Therapy in Multiple Sclerosis"],"prefix":"10.1210","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7619-8701","authenticated-orcid":false,"given":"Sara Salehi","family":"Hammerstad","sequence":"first","affiliation":[{"name":"Division of Peadiatric and Adolescent Medicine, Oslo University Hospital, Ullev\u00e5l, Oslo, Norway"},{"name":"Specialist Center Pilestredet Park, OsloNorway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth G","family":"Celius","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oslo University Hospital, Ullev\u00e5l, Oslo; Norway and University of Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Husby","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine, Oslo University Hospital, Ullev\u00e5l, OsloNorway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingvild M","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Division of Peadiatric and Adolescent Medicine, Oslo University Hospital, Ullev\u00e5l, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid E","family":"Norheim","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Aker, Oslo, 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