{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:55:23Z","timestamp":1762005323682,"version":"3.41.2"},"reference-count":11,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cushing\u2019s syndrome (CS) is known to involve periodic cortisol secretion in some patients. It has also been demonstrated that resolution of cortisol hypersecretion in CS may cause autoimmune-related disease to become apparent. At least 3 cases of psoriasis that became apparent after resolution of hypercortisolism in CS have been reported. We describe a 45-year-old man with cyclic Cushing\u2019s disease in whom psoriasis vulgaris, an autoimmune-related disease, was ameliorated during a period of hypercortisolemia. He had complained of intermittent sensations of \u201cwhole-body swelling\u201d and improvement of his psoriatic skin lesions, which lasted 2 to 3 weeks at 2- to 3-month intervals over several years. During a 2-week hospitalization for endocrine investigations, an episode of hypercortisolemia appeared unexpectedly. During this time period, the peak serum cortisol level reached 75.7 \u00b5g\/mL (adrenocorticotropic hormone level, 585 pg\/mL) and 24-hour urinary free cortisol reached 10 500 \u00b5g\/day. A diagnosis of Cushing\u2019s disease was made based on a markedly elevated urinary free cortisol level, an adequate increase in adrenocorticotropic hormone level in response to corticotropin-releasing hormone stimulation, and the presence of a giant pituitary tumor with a maximum diameter of approximately 4 cm. Interestingly, during this time period, there was a marked improvement in the psoriatic skin lesions and whole-body swelling sensations.<\/jats:p>","DOI":"10.1210\/jendso\/bvab058","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T19:26:24Z","timestamp":1617218784000},"source":"Crossref","is-referenced-by-count":3,"title":["Case of Cyclic Cushing\u2019s Disease with Improvement of Psoriatic Skin Lesions During a Period of Hypercortisolemia"],"prefix":"10.1210","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8562-2658","authenticated-orcid":false,"given":"Nobuhiro","family":"Nakatake","sequence":"first","affiliation":[{"name":"Department of Psychosomatic Medicine and Endocrinology, Fukuoka Tokushukai Hospital, Fukuoka 816\u20130864, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4514-8984","authenticated-orcid":false,"given":"Fumihiro","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgical, Fukuoka Neurosurgical Hospital, Fukuoka 811\u20131313, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigetoshi","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Neurosurgical, Fukuoka Neurosurgical Hospital, Fukuoka 811\u20131313, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Endocrinology, Fukuoka Tokushukai Hospital, Fukuoka 816\u20130864, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0896-2816","authenticated-orcid":false,"given":"Sunao","family":"Matsubayashi","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Endocrinology, Fukuoka Tokushukai Hospital, Fukuoka 816\u20130864, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"issue":"3","key":"2021070815571262100_CIT0001","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1210\/jcem-32-3-317","article-title":"Periodic hormonogenesis\u2013a new phenomenon. periodicity in function of a hormone-producing tumor in man","volume":"32","author":"Bailey","year":"1971","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2021070815571262100_CIT0002","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1530\/EJE-07-0262","article-title":"Cyclic Cushing\u2019s syndrome: a 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immunologically-mediated disease: three cases]","volume":"130","author":"Sahli","year":"2005","journal-title":"Dtsch Med Wochenschr."},{"issue":"6","key":"2021070815571262100_CIT0006","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1530\/EJE-09-0046","article-title":"The prevalence and characteristic features of cyclicity and variability in Cushing\u2019s disease","volume":"160","author":"Alexandraki","year":"2009","journal-title":"Eur J Endocrinol."},{"issue":"2","key":"2021070815571262100_CIT0007","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0022-3476(89)80081-2","article-title":"Periodic Cushing syndrome in a short boy: usefulness of the ovine corticotropin releasing hormone test","volume":"115","author":"Gomez Muguruza","year":"1989","journal-title":"J Pediatr."},{"issue":"4","key":"2021070815571262100_CIT0008","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/PL00002112","article-title":"Primary pigmented nodular adrenocortical 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